PMID: 9529945Apr 8, 1998Paper

Prefrontal cortex glucose metabolism and startle eyeblink modification abnormalities in unmedicated schizophrenia patients

Psychophysiology
E A HazlettB T Troyer

Abstract

Attentional modulation of the startle reflex was studied in 16 unmedicated schizophrenia patients and 15 control individuals during the 18F-2-deoxyglucose uptake period for positron emission tomography. In a task involving attended, ignored, and novel tones that served as prepulses, control individuals showed greater prepulse inhibition (PPI) at 120 ms and greater prepulse facilitation at 4,500 ms during attended than during ignored prepulses; the amount of PPI and facilitation during novel prepulses was intermediate. In contrast, patients failed to show differential PPI at 120 ms and tended to show greater facilitation at 4,500 ms during novel prepulses. For control individuals, greater PPI was associated with higher relative metabolic activity rates in prefrontal (Brodmann Areas 8, 9, and 10 bilaterally) and lower in visual cortex. Patients showed this relationship only for Area 10 on the left. Patients also had low metabolism in superior, middle, and inferior prefrontal cortex. Consistent with animal models, our results demonstrate the importance of the functional integrity of prefrontal cortex to PPI modulation.

Citations

Oct 10, 2009·Psychopharmacology·Kirsty Elizabeth Scholes, Mathew Thomas Martin-Iverson
Nov 13, 2004·European Archives of Psychiatry and Clinical Neuroscience·Ulrich MeinckeEuphrosyne Gouzoulis-Mayfrank
Oct 8, 2004·Schizophrenia Research·Veena KumariTonmoy Sharma
Oct 26, 2002·Biological Psychiatry·Bob OranjeRené S Kahn
Apr 12, 2003·Neuropharmacology·Kathryn M AbelMark A Geyer
Aug 16, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Martin VolzEibe-Rudolf Rey
Aug 7, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·A H BöhmeltM E Dawson
Sep 10, 2003·Progress in Neurobiology·Tobias Bast, Joram Feldon
Aug 27, 1999·Progress in Neurobiology·M Koch
Sep 29, 2001·Brain Research Bulletin·N UranovaV Rachmanova
Apr 26, 2003·Psychiatry Research·Lara L Davidson, R Walter Heinrichs
Dec 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Veena KumariAnthony J Cleare
Dec 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eva RomeroJosé Borrell
Nov 17, 2001·Neuroreport·R WeisserM Scherg
Jul 4, 2003·The Journal of Clinical Investigation·Tonmoy Sharma
Sep 16, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mesbah AlamKerstin Schwabe
Dec 21, 2013·Expert Opinion on Pharmacotherapy·Naren P Rao, Gary Remington
May 4, 2013·Expert Opinion on Investigational Drugs·Naren P Rao, Gary Remington
Jan 22, 2013·Brain Research·Miho OtaHiroshi Kunugi
Nov 9, 2011·Neuroscience Research·Hidetoshi TakahashiMasatoshi Takeda
Oct 27, 2009·Neurophysiologie clinique = Clinical neurophysiology·S CampanellaX Noël
Mar 10, 2009·Neurophysiologie clinique = Clinical neurophysiology·S Campanella, J-M Guerit
Nov 13, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·V MolinaD E López
Jan 29, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Veena KumariMark A Geyer
Dec 2, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Judith BuseVeit Roessner
Jul 13, 2005·Psychophysiology·Ulrich EttingerPhilip J Corr

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