PMID: 2119850Jun 25, 1990Paper

Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress

Brain Research
A Y DeutchR H Roth

Abstract

Mild footshock stress results in the metabolic activation of the prefrontal cortical dopamine (DA) innervation, but does not augment DA utilization in mesolimbic areas (such as the nucleus accumbens septi, NAS) or the striatum. However, increases in either the intensity or duration of footshock stress increase DA utilization in the subcortical sites. DA afferents to the prefrontal cortex (PFC) hold corticofugal projection neurons under tonic inhibition. Previous data suggest that removal of these corticofugal glutamatergic neurons from tonic DA inhibition results in a transsynaptic alteration in the NAS, such that the DA innervation of the NAS is rendered hyperresponsive to certain perturbations. We therefore examined the effects of stress on subcortical DA systems in rats previously subjected to 6-hydroxydopamine lesions of the PFC DA innervation. Mild footshock stress resulted in an increase in concentrations of the DA metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the PFC, but not NAS or striatum, of sham-lesioned animals. Footshock resulted in a significant increase in the concentration of DOPAC in the nucleus accumbens of animals sustaining PFC lesions two weeks previously. The PFC lesion did not result in a stress-i...Continue Reading

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Citations

Sep 19, 2003·Current Psychiatry Reports·Kimberly P LindseyNora D Volkow
Jun 11, 1993·European Journal of Pharmacology·T Hamamura, H C Fibiger
Jun 3, 1996·European Journal of Pharmacology·K WedzonyK Gołembiowska
Aug 1, 1996·European Journal of Pharmacology·J M MathéT H Svensson
Jan 1, 1995·Life Sciences·C J SchmidtM G Palfreyman
Jun 1, 1995·Physiology & Behavior·S Sudha, N Pradhan
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·B K LipskaD R Weinberger
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·A R BraunD R Weinberger
Aug 1, 1994·Pharmacology, Biochemistry, and Behavior·B K LipskaD R Weinberger
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·R J CareyJ P Huston
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·W J Freed
Feb 1, 1995·Schizophrenia Research·A Breier
Mar 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M KurachiY Sakurai

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