Event-related potentials and behavioral measures were obtained from young and elderly subjects while they performed two different auditory delayed match-to-sample tasks. In each experiment, subjects had to indicate whether an initial and a subsequent test sound were identical in two different conditions: one filled with distracting tone pips and one with no distractors. Electrophysiologically, elderly subjects had reduced attention-related activity over frontal regions. In addition, the distracting stimuli elicited an enhanced primary auditory evoked response in the elderly. The percentage of perseverative errors on the Wisconsin card sorting test, a putative measure of frontal lobe function, was positively correlated with the amplitude of the primary auditory evoked response in elderly subjects. Behaviorally, elderly subjects were impaired by distractors at long but not short delays. Taken together, these results suggest that increased distractibility and impaired sustained attention with aging may be due to altered prefrontal cortex function. These data support the loss of prefrontal suppression over the primary auditory regions with aging.
Auditory distraction in young and middle-aged adults: a behavioural and event-related potential study
Effects of age, age-related hearing loss, and contralateral cafeteria noise on the discrimination of small frequency changes: psychoacoustic and electrophysiological measures
Trail Making Test in traumatic brain injury, schizophrenia, and normal ageing: sample comparisons and normative data
Event-related brain response abnormalities in autism: evidence for impaired cerebello-frontal spatial attention networks
Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects
Processing speed and visuospatial executive function predict visual working memory ability in older adults
Qualitative neuropsychological measures: normative data on executive functioning tests from the Framingham offspring study
Right temporal cortex is critical for utilization of melodic contextual cues in a pitch constancy task
Age effects on preattentive and early attentive auditory processing of redundant stimuli: is sensory gating affected by physiological aging?
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging
Reduced suppression or labile memory? Mechanisms of inefficient filtering of irrelevant information in older adults
Quantitative gait analysis under dual-task in older people with mild cognitive impairment: a reliability study
Age-related differences in cortical activity during a visuo-spatial working memory task with facial stimuli
Age-Sensitive Effects of Enduring Work with Alternating Cognitive and Physical Load. A Study Applying Mobile EEG in a Real Life Working Scenario
Electrophysiological Indicators of the Age-Related Deterioration in the Sensitivity to Auditory Duration Deviance
The prefrontal cortex is required for incidental encoding but not recollection of source information in rodents
Driving in fog: the effects of driving experience and visibility on speed compensation and hazard avoidance
Individual differences in aging and cognitive control modulate the neural indexes of context updating and maintenance during task switching
Effects of age and background noise on processing a mistuned harmonic in an otherwise periodic complex sound
Environmental noise-exposed workers: event-related potentials, neuropsychological and mood assessment
Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence
Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats
Age-related effects of novel visual stimuli in a letter-matching task: an event-related potential study
Correlation of auditory event-related potentials and magnetic resonance spectroscopy measures in mild cognitive impairment
Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities
The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan
Selective increase of cortical thickness in high-performing elderly--structural indices of optimal cognitive aging
Happy and less inhibited? Effects of positive mood on inhibitory control during an antisaccade task revealed using topographic evoked potential mapping
Examining the relationships between self-efficacy, task-relevant attentional control , and task performance: Evidence from event-related brain potentials
Attention-based modulation of tactile stimuli: a comparison between prefrontal lesion patients and healthy age-matched controls
Age-related loss in attention-based modulation of tactile stimuli at early stages of somatosensory processing
White matter hyperintensities are associated with visual search behavior independent of generalized slowing in aging
Ameliorative effect of traditional Japanese medicine yokukansan on age-related impairments of working memory and reversal learning in rats
Novel sounds as a psychophysiological measure of listening effort in older listeners with and without hearing loss
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline
Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan
Aging redistributes medial prefrontal neuronal excitability and impedes extinction of trace fear conditioning
Age-related differences in attentional networks of alerting and executive control in young, middle-aged, and older Chinese adults
Subcortical white matter pathology as a mediating factor for age-related decreased performance in dichotic listening
Comparable mechanisms of working memory interference by auditory and visual motion in youth and aging
Modality-specificity of sensory aging in vision and audition: evidence from event-related potentials
The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values
Age-related differences in early novelty processing: using PCA to parse the overlapping anterior P2 and N2 components
The role of reduced working memory storage and processing resources in the associative memory deficit of older adults: simulation studies with younger adults
The Importance of Aging in Gray Matter Changes Within Tinnitus Patients Shown in Cortical Thickness, Surface Area and Volume
Auditory evoked potentials in females with high and low acceptance of background noise when listening to speech
Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder
Reduced temporal processing in older, normal-hearing listeners evident from electrophysiological responses to shifts in interaural time difference
Interference resolution in the elderly: evidence suggestive of differences in strategy on measures of prepotent inhibition and dual task processing
Association of Cataract Surgical Outcomes With Late Surgeon Career Stages: A Population-Based Cohort Study
Relationship of prefrontal connections to inhibitory systems in superior temporal areas in the rhesus monkey
Effects of Meditation and Mind-Body Exercises on Older Adults' Cognitive Performance: A Meta-analysis
Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory
Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?
Episodic memory, concentrated attention and processing speed in aging: A comparative study of Brazilian age groups
Acute Effects of Tai Chi Training on Cognitive and Cardiovascular Responses in Late Middle-Aged Adults: A Pilot Study
Identification of the Spectrotemporal Modulations That Support Speech Intelligibility in Hearing-Impaired and Normal-Hearing Listeners
Age-related processing delay reveals cause of apparent sensory excitability following auditory stimulation
Dysfunction of Inferior Parietal Lobule During Sensory Gating in Patients With Amnestic Mild Cognitive Impairment
Fronto-temporal brain activity and connectivity track implicit attention to positive and negative social words in a novel socio-emotional Stroop task.
Behavioral and electrophysiological correlates of Simon and flanker conflict interference in younger and older adults.
Event-related potential evidence that very slowly presented auditory stimuli are passively processed differently in younger and older adults.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.
Chronic Fatigue Syndrome
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Spatio-Temporal Regulation of DNA Repair
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Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.
Hereditary Sensory Autonomic Neuropathy
Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.
Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Applications of Molecular Barcoding
The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.