Prefrontal Engagement and Reduced Default Network Suppression Co-occur and Are Dynamically Coupled in Older Adults: The Default-Executive Coupling Hypothesis of Aging

Journal of Cognitive Neuroscience
Gary R Turner, R Nathan Spreng

Abstract

Reduced executive control is a hallmark of neurocognitive aging. Poor modulation of lateral pFC activity in the context of increasing task challenge in old adults and a "failure to deactivate" the default network during cognitive control tasks have been observed. Whether these two patterns represent discrete mechanisms of neurocognitive aging or interact into older adulthood remains unknown. We examined whether altered pFC and default network dynamics co-occur during goal-directed planning over increasing levels of difficulty during performance on the Tower of London task. We used fMRI to investigate task- and age-related changes in brain activation and functional connectivity across four levels of task challenge. Frontoparietal executive control regions were activated and default network regions were suppressed during planning relative to counting performance in both groups. Older adults, unlike young, failed to modulate brain activity in executive control and default regions as planning demands increased. Critically, functional connectivity analyses revealed bilateral dorsolateral pFC coupling in young adults and dorsolateral pFC to default coupling in older adults with increased planning complexity. We propose a default-exec...Continue Reading

References

Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Shallice
Jun 1, 1996·Neuropsychologia·S C BakerT W Robbins
Apr 19, 2000·Journal of Cognitive Neuroscience·P A Reuter-LorenzR A Koeppe
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Dec 13, 2002·Brain : a Journal of Neurology·Alexa M MorcomMichael D Rugg
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Cindy LustigRandy L Buckner
Aug 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Denise C ParkMason R Smith
Mar 8, 2005·Cerebral Cortex·Yaakov SternRonald van Heertum
Apr 16, 2005·Current Opinion in Neurobiology·Patricia A Reuter-Lorenz, Cindy Lustig
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Oct 11, 2005·Neuroscience Letters·Venkata S MattayDaniel R Weinberger
Feb 8, 2006·Trends in Cognitive Sciences·Fergus I M Craik, Ellen Bialystok
Jan 20, 2007·Science·Malia F MasonC Neil Macrae
Jun 1, 2007·Journal of Cognitive Neuroscience·Jonas PerssonPatricia A Reuter-Lorenz
Aug 4, 2007·Cognitive, Affective & Behavioral Neuroscience·Bradley C Love, Todd M Gureckis
Dec 7, 2007·Neuron·Jessica R Andrews-HannaRandy L Buckner
Dec 8, 2007·Cerebral Cortex·J S DamoiseauxS A R B Rombouts
Feb 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Saul L MillerReisa A Sperling
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 5, 2008·Neurobiology of Aging·Fabio SambataroVenkata S Mattay
Sep 19, 2008·Journal of Neurophysiology·Justin L VincentRandy L Buckner
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Dale StevensCheryl L Grady
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kalina ChristoffJonathan W Schooler
Jan 26, 2010·Magnetic Resonance Imaging·Ludmila I Kuncheva, Juan J Rodríguez
Jan 26, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Katherine A CappellPatricia A Reuter-Lorenz
Mar 2, 2010·Neuron·Jessica R Andrews-HannaRandy L Buckner
May 4, 2010·NeuroImage·David J MaddenRoberto Cabeza
May 18, 2010·Neurobiology of Aging·Nancy A Dennis, Roberto Cabeza
Jul 27, 2010·NeuroImage·Anjali KrishnanHervé Abdi
May 31, 2011·Nature Neuroscience·James Z Chadick, Adam Gazzaley
Jul 28, 2011·Neurobiology of Aging·Gary R Turner, R Nathan Spreng
Aug 16, 2011·Neurobiology of Aging·Jessica S DamoiseauxMichael D Greicius
Dec 1, 2011·Cerebral Cortex·R Nathan Spreng, Daniel L Schacter
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Meghan L MeyerMatthew D Lieberman

❮ Previous
Next ❯

Citations

Sep 26, 2015·Neuropsychologia·Manuela Piazza, Evelyn Eger
Jun 19, 2016·Neurobiology of Aging·Courtney L GallenMark D'Esposito
Jun 11, 2016·Trends in Cognitive Sciences·David Maillet, Daniel L Schacter
Jan 26, 2017·Frontiers in Aging Neuroscience·Tali Siman-TovItamar Kahn
Sep 5, 2017·Neurorehabilitation and Neural Repair·Areeba AdnanGary R Turner
Sep 19, 2017·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Arnaud Boujut, David Clarys
Feb 21, 2019·Social Cognitive and Affective Neuroscience·Areeba AdnanGary R Turner
Mar 29, 2019·Cerebral Cortex·Tarek AmerCheryl L Grady
Apr 24, 2019·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·R Nathan Spreng, Gary R Turner
Mar 11, 2018·Human Brain Mapping·Takahiro EzakiNaoki Masuda
May 14, 2020·Social Cognitive and Affective Neuroscience·Anne C LauritaR Nathan Spreng
Nov 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Aaron KucyiEve M Valera
Jun 20, 2017·Language, Cognition and Neuroscience·Karen L Campbell, Daniel L Schacter
Jun 20, 2019·Frontiers in Aging Neuroscience·Bryant M DudaLawrence H Sweet
Sep 27, 2019·Frontiers in Psychology·Filippo Cieri, Roberto Esposito
Jan 23, 2018·Frontiers in Aging Neuroscience·Alexandru D IordanPatricia A Reuter-Lorenz
Mar 19, 2019·Frontiers in Aging Neuroscience·Claudine HabakOury Monchi
Jun 12, 2019·Wiley Interdisciplinary Reviews. Cognitive Science·Liyana T Swirsky, Julia Spaniol
Nov 15, 2020·Cerebral Cortex·Gaelle E DoucetUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 13, 2019·Neuropsychologia·Sabrina Lemire-RodgerGary R Turner
Apr 16, 2018·Neuropsychologia·Margaret A O'Connell, Chandramallika Basak
Apr 6, 2021·Brain Connectivity·Ryan Michael Wales, Hoi-Chung Leung
Nov 6, 2018·Neurobiology of Aging·Margot D SullivanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 11, 2021·GeroScience·Monica BaciuJean-François Démonet
May 8, 2020·NeuroImage·Alexandru D IordanPatricia A Reuter-Lorenz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.