Prefrontal hypoactivation during working memory in bipolar II depression

Psychological Medicine
J O BrooksLori L Altshuler

Abstract

Patterns of abnormal neural activation have been observed during working memory tasks in bipolar I depression, yet the neural changes associated with bipolar II depression have yet to be explored. An n-back working memory task was administered during a 3T functional magnetic resonance imaging scan in age- and gender-matched groups of 19 unmedicated, bipolar II depressed subjects and 19 healthy comparison subjects. Whole-brain and region-of-interest analyses were performed to determine regions of differential activation across memory-load conditions (0-, 1- and 2-back). Accuracy for all subjects decreased with higher memory load, but there was no significant group × memory load interaction. Random-effects analyses of memory load indicated that subjects with bipolar II depression exhibited significantly less activation than healthy subjects in left hemispheric regions of the middle frontal gyrus [Brodmann area (BA) 11], superior frontal gyrus (BA 10), inferior parietal lobule (BA 40), middle temporal gyrus (BA 39) and bilateral occipital regions. There was no evidence of differential activation related to increasing memory load in the dorsolateral prefrontal or anterior cingulate cortex. Bipolar II depression is associated with h...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
May 1, 1996·Psychological Medicine·A J RushM H Trivedi
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E E Smith, J Jonides
Jul 23, 1999·Annals of the New York Academy of Sciences·W C Drevets
Jan 5, 2000·Psychological Medicine·F C MurphyE S Paykel
Sep 2, 2000·Current Opinion in Neurology·R Cabeza, L Nyberg
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 24, 2002·Journal of Cognitive Neuroscience·Kevin N OchsnerJohn D E Gabrieli
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Oct 22, 2003·NeuroImage·Christian F BeckmannStephen M Smith
Jun 14, 2005·Consciousness and Cognition·Hamid Reza Naghavi, Lars Nyberg
Sep 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Carla TorrentEduard Vieta
Dec 17, 2008·Human Brain Mapping·Sonja SchöningCarsten Konrad
Apr 28, 2009·Nature Neuroscience·Nikolaus KriegeskorteChris I Baker
Jul 15, 2009·Bipolar Disorders·Sandra DittmannHeinz C Grunze
Jul 15, 2009·Bipolar Disorders·Thilo DeckersbachDarin D Dougherty
Jul 25, 2009·Bipolar Disorders·Yih-Lynn HsiaoRu-Band Lu
Oct 19, 2010·Journal of Psychiatric Research·Denise Balem YatesClarissa Marceli Trentini
Nov 17, 2010·The American Journal of Psychiatry·Amy GarrettAllan L Reiss
Jan 29, 2011·Psychological Medicine·B SoléE Vieta
Aug 10, 2011·IET Systems Biology·K Oishi, E Klavins
Aug 19, 2011·Acta Psychiatrica Scandinavica·B SoléE Vieta
Aug 3, 2012·Journal of Affective Disorders·Paloma Fernández-CorcueraEdith Pomarol-Clotet

❮ Previous
Next ❯

Citations

Sep 11, 2018·CNS Spectrums·Kamilla W Miskowiak, Cecilia S Petersen
Mar 9, 2019·Bipolar Disorders·Silvia Alonso-LanaEdith Pomarol-Clotet
Jul 18, 2017·Bipolar Disorders·Elena Rodríguez-CanoEdith Pomarol-Clotet
Jul 14, 2021·NeuroImage. Clinical·Zachary Adam YapleRongjun Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.