Prefrontal Modulation of Visual Processing and Sustained Attention in Aging, a tDCS-EEG Coregistration Approach

Journal of Cognitive Neuroscience
Méadhbh B BrosnanPaul Dockree

Abstract

The ability to sustain attention is integral to healthy cognition in aging. The right PFC (rPFC) is critical for maintaining high levels of attentional focus. Whether plasticity of this region can be harnessed to support sustained attention in older adults is unknown. We used transcranial direct current stimulation to increase cortical excitability of the rPFC, while monitoring behavioral and electrophysiological markers of sustained attention in older adults with suboptimal sustained attention capacity. During rPFC transcranial direct current stimulation, fewer lapses of attention occurred and electroencephalography signals of frontal engagement and early visual attention were enhanced. To further verify these results, we repeated the experiment in an independent cohort of cognitively typical older adults using a different sustained attention paradigm. Again, prefrontal stimulation was associated with fewer attentional lapses. These experiments suggest the rPFC can be manipulated in later years to increase top-down modulation over early sensory processing and improve sustained attention performance. This holds valuable information for the development of neurorehabilitation protocols to ameliorate age-related deficits in this c...Continue Reading

References

Jan 1, 1990·Annual Review of Neuroscience·M I Posner, S E Petersen
Jan 1, 1987·Neuropsychologia·A J WilkinsR McCarthy
Oct 1, 1996·Neuropsychologia·L Rueckert, J Grafman
Jul 1, 1997·Accident; Analysis and Prevention·G D Edkins, C M Pollock
Sep 2, 1998·Neuropsychologia·L Rueckert, J Grafman
May 25, 2001·NeuroImage·W Sturm, K Willmes
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Nov 15, 2003·Journal of Cognitive Neuroscience·Natalia S LawrenceElliot A Stein
Jun 9, 2004·Brain Research. Cognitive Brain Research·C FassbenderH Garavan
Aug 24, 2004·Current Opinion in Neurobiology·L M HurleyB D Waterhouse
Jan 15, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Evelijne M BekkerMarinus N Verbaten
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Oct 4, 2005·Biological Psychology·Kirk R DaffnerPhillip J Holcomb
Oct 21, 2005·Neuropsychologia·Thomas Habekost, Egill Rostrup
Nov 2, 2005·Annals of Neurology·Paresh A MalhotraMasud Husain
Jan 24, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Prateek C GandigaLeonardo G Cohen
Mar 10, 2007·Brain : a Journal of Neurology·F M O'KeeffeI H Robertson
Apr 4, 2007·Journal of Pediatric Psychology·David C SchwebelJennifer Simpson
Oct 14, 2008·International Journal of Geriatric Psychiatry·Cheryl A LuisMichael Mullan
Oct 30, 2008·Frontiers in Human Neuroscience·Rajeev D S Raizada, Russell A Poldrack
Nov 13, 2008·Journal of Experimental Psychology. General·Frederick Verbruggen, Gordon D Logan
Jan 14, 2009·Neuropsychologia·Victoria Singh-Curry, Masud Husain
Jan 23, 2009·Brain : a Journal of Neurology·Paresh MalhotraMasud Husain
Feb 5, 2009·Nature Reviews. Neuroscience·Susan J Sara
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Redmond G O'ConnellSimon P Kelly
Aug 18, 2009·Neuropsychologia·Ellen MatthiasKathrin Finke
May 11, 2010·Neuropsychologia·Daniel SmilekJ Allan Cheyne
Jun 22, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Victoria Singh-CurryMasud Husain
Jul 21, 2010·PloS One·Anne S BerryAdam Gazzaley
Dec 16, 2010·International Journal of Geriatric Psychiatry·Robert F CoenBrian A Lawlor
Apr 6, 2011·Neuropsychology·Charlene O'ConnorBrian Levine
Jun 23, 2011·Annual Review of Neuroscience·Maurizio Corbetta, Gordon L Shulman
Dec 6, 2011·Cerebral Cortex·Lynley V BradnamWinston D Byblow
Dec 21, 2011·BMC Geriatrics·Aisling M O'HalloranRose Anne Kenny
Mar 26, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Aisling M O'HalloranRose Anne Kenny

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Citations

Jul 2, 2020·Journal of Circadian Rhythms·Mojtaba Elhami AtharAhmad Ashouri
Oct 20, 2020·Cerebral Cortex Communications·Nir ShalevMagdalena Chechlacz
Mar 7, 2021·Neuropsychologia·Gianvito LaeraAlexandra Hering
Mar 23, 2021·Journal of the International Neuropsychological Society : JINS·M B BrosnanN Demeyere
Jul 26, 2021·Neuropsychologia·Marco EspositoDebora Brignani

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Software Mentioned

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