Although altered function in neural reward circuitry is widely proposed in models of addiction, more recent conceptual views have emphasized the role of disrupted response in prefrontal regions. Changes in regions such as the orbitofrontal cortex, medial prefrontal cortex, and dorsolateral prefrontal cortex are postulated to contribute to the compulsivity, impulsivity, and altered executive function that are central to addiction. In addition, few studies have examined function in these regions during young adulthood, when exposure is less chronic than in typical samples of alcohol-dependent adults. To address these issues, we examined neural response and functional connectivity during monetary reward in 24 adults with alcohol dependence and 24 psychiatrically healthy adults. Adults with alcohol dependence exhibited less response to the receipt of monetary reward in a set of prefrontal regions including the medial prefrontal cortex, lateral orbitofrontal cortex, and dorsolateral prefrontal cortex. Adults with alcohol dependence also exhibited greater negative correlation between function in each of these regions and that in the nucleus accumbens. Within the alcohol-dependent group, those with family history of alcohol dependence...Continue Reading
Dissociable functions in the medial and lateral orbitofrontal cortex: evidence from human neuroimaging studies
Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues
Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics
Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving
Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents
Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity
Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder
Healthy adolescents' neural response to reward: associations with puberty, positive affect, and depressive symptoms
Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies
Positive emotionality is associated with baseline metabolism in orbitofrontal cortex and in regions of the default network
Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder
Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors
Balkanizing the primate orbitofrontal cortex: distinct subregions for comparing and contrasting values
Nucleus accumbens response to incentive stimuli anticipation in children of alcoholics: relationships with precursive behavioral risk and lifetime alcohol use
Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients
Substrates of neuropsychological functioning in stimulant dependence: a review of functional neuroimaging research
Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals
Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task
Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity
Traumatic Brain Injury and Post-Deployment Binge Drinking among Male and Female Army Active Duty Service Members Returning from Operation Enduring Freedom/Operation Iraqi Freedom
Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum
The potential of neuroimaging for identifying predictors of adolescent alcohol use initiation and misuse
Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers
Accelerated alcohol use across adolescence predicts early adult symptoms of alcohol use disorder via reward-related neural function
Water-fat separation in spiral magnetic resonance fingerprinting for high temporal resolution tissue relaxation time quantification in muscle.
Do alcohol-dependent patients show different neural activation during response inhibition than healthy controls in an alcohol-related fMRI go/no-go-task?
Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations
Internet Game Overuse Is Associated With an Alteration of Fronto-Striatal Functional Connectivity During Reward Feedback Processing
Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study
Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study
Striatal activation and frontostriatal connectivity during non-drug reward anticipation in alcohol dependence
Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment
Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats.
Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent.
Goal-striving tendencies moderate the relationship between reward-related brain function and peripheral inflammation.
Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure.
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.
This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.
Amygdala and Midbrain Dopamine
The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.
Alcohol Use Disorder
Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.