Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans.

Neuron
Witney ChenPhilip A Starr

Abstract

The ability to dynamically change motor outputs, such as stopping an initiated response, is an important aspect of human behavior. A hyperdirect pathway between the inferior frontal gyrus and subthalamic nucleus is hypothesized to mediate movement inhibition, but there is limited evidence for this in humans. We recorded high spatial and temporal resolution field potentials from both the inferior frontal gyrus and subthalamic nucleus in 21 subjects. Cortical potentials evoked by subthalamic stimulation revealed short latency events indicative of monosynaptic connectivity between the inferior frontal gyrus and ventral subthalamic nucleus. During a stop signal task, stopping-related potentials in the cortex preceded stopping-related activity in the subthalamic nucleus, and synchronization between these task-evoked potentials predicted the stop signal reaction time. Thus, we show that a prefrontal-subthalamic hyperdirect pathway is present in humans and mediates rapid stopping. These findings may inform therapies to treat disorders featuring perturbed movement inhibition.

Citations

Sep 20, 2020·Experimental Brain Research·Carly IaculloJan R Wessel
Aug 11, 2020·Experimental Brain Research·Indrajeet Indrajeet, Supriya Ray
Dec 1, 2020·Brain : a Journal of Neurology·Roxanne LofrediAndrea A Kühn
Feb 12, 2021·Journal of Cognitive Neuroscience·Matthias LiebrandUlrike M Krämer
Jan 1, 2021·Cerebral Cortex Communications·Nelleke C van WouweScott A Wylie
May 5, 2021·Psychophysiology·Mikael Lundqvist, Andreas Wutz
Jun 19, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Matteo EspositoAlessia Celeghin
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