Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized controlled trial

European Journal of Ophthalmology
Mohammad PakravanMehdi Yaseri

Abstract

To evaluate the efficacy of pregabalin and gabapentin for reducing post-photorefractive keratectomy (PRK) pain. In this randomized clinical trial, 150 subjects undergoing PRK were allocated into 3 groups. In addition to the routine regimen, pregabalin 75 mg, gabapentin 300 mg, and placebo were administered 3 times daily for 3 days, in groups 1, 2, and 3, respectively. Subjects could take acetaminophen-codeine 300/10 mg tablets every 4 hours as needed. Patients completed a pain assessment survey (visual analogue scale ranging from 0 = no pain to 10 = most severe pain) 7 times in the first 3 days following PRK and also recorded the number of consumed acetaminophen-codeine tablets. Age, sex, refractive error, ablation depth, and mitomycin-C (MMC) application were similar in the 3 study groups (all p values>0.05). Overall pain scores in the placebo group were 0.9 and 1 unit higher than the pregabalin (p=0.029) and gabapentin (p=0.023) groups, respectively. Severe pain (score >7) was more frequent in the placebo group on the morning of the first postoperative day (p=0.043). The difference in the number of consumed acetaminophen-codeine tablets was statistically borderline (p=0.061) and less in the pregabalin (7.9 ± 5.2) and gabapent...Continue Reading

References

Jul 24, 2001·European Journal of Pain : EJP·C M HillG Murray
Jan 11, 2002·The Clinical Journal of Pain·M A MellegersA Mailis
May 22, 2003·Seminars in Ophthalmology·Renato Ambrósio, Steven Wilson
Jul 30, 2004·The New England Journal of Medicine·Steven E Wilson
Aug 18, 2004·Journal of Cataract and Refractive Surgery·Kerry D SolomonUNKNOWN Ketorolac Reformulation Study Groups 1 and 2
Aug 19, 2004·Epilepsia·Elinor Ben-Menachem
Dec 22, 2004·Drugs·James E Frampton, Rachel H Foster
Nov 17, 2005·The Annals of Pharmacotherapy·Bassel F Shneker, James W McAuley
Apr 4, 2007·Trends in Pharmacological Sciences·Anthony DaviesAnnette C Dolphin
Nov 29, 2007·Anesthesia and Analgesia·Noor M Gajraj
Jan 30, 2008·American Journal of Ophthalmology·Steven A NissmanJoseph F Pasternak
Sep 8, 2010·Clinical Pharmacokinetics·Howard N BockbraderPaula Burger
Jan 19, 2011·Journal of Cataract and Refractive Surgery·Matthew D KuhnleKraig S Bower

❮ Previous
Next ❯

Citations

Jun 20, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Juan Carlos Serna-OjedaEnrique O Graue-Hernandez
Jun 10, 2015·Current Opinion in Ophthalmology·Jonathan Fay, Viral Juthani
Feb 13, 2019·Indian Journal of Psychiatry·Jon E Grant
Mar 5, 2016·International Ophthalmology Clinics·C Andres Benatti, Natalie A Afshari
Sep 30, 2014·Journal of Cataract and Refractive Surgery·Ella G Faktorovich, Karishma Melwani
Feb 25, 2015·The British Journal of Ophthalmology·Anat GalorRoy C Levitt
Apr 15, 2015·Current Medical Research and Opinion·Hili GiladiYoram Shir
Dec 12, 2017·Current Ophthalmology Reports·Deborah S Jacobs
Jul 8, 2014·Ophthalmic Plastic and Reconstructive Surgery·Leslie A WeiVikram D Durairaj
Jun 11, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Julie M MeekCharles D Reilly
Nov 5, 2017·Clinical Oral Investigations·Sara Liébana-HermosoMaria Victoria Olmedo-Gaya
May 1, 2018·Current Opinion in Ophthalmology·Oren Golan, J Bradley Randleman
Sep 18, 2015·The British Journal of Ophthalmology·Anat GalorRoy C Levitt
Mar 26, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Wenjia Xie
Sep 9, 2020·Current Opinion in Ophthalmology·Jerome KulenkampMichael S Lee
Dec 4, 2020·Journal of Clinical Medicine·Hyeon-Jeong YoonKyung Chul Yoon
Oct 4, 2020·Current Opinion in Ophthalmology·Jerome KulenkampMichael S Lee
Mar 13, 2021·Current Opinion in Ophthalmology·Matthew R StarrYoshihiro Yonekawa
Jun 25, 2021·Frontiers in Pharmacology·Maurizio CammalleriDario Rusciano
Nov 11, 2021·Journal of Refractive Surgery·Mehrdad MohammadpourRenato Ambrósio

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01122004

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cataract and Refractive Surgery
Dong H LeeJong G Kim
Journal of Anaesthesiology, Clinical Pharmacology
Sidharth S RoutraySunita Nayak
Journal of Cataract and Refractive Surgery
Matthew D KuhnleKraig S Bower
© 2021 Meta ULC. All rights reserved