Pregabalin for painful diabetic peripheral neuropathy: strategies for dosing, monotherapy vs. combination therapy, treatment-refractory patients, and adverse events

Current Medical Research and Opinion
Mark S JuhnAlesia Sadosky

Abstract

Primary care physicians face significant challenges when treating painful diabetic peripheral neuropathy (pDPN). The physician must determine the best dosing strategy, consider the use of combination therapy, and decide how best to treat patients who have responded poorly to other treatment options in the past. With a focus on these issues, this paper will review the use of pregabalin for the treatment of pDPN in order to provide physicians with clinical data needed to develop, in combination with real-world prescribing data, effective treatment strategies for this common but challenging type of pain. A formal PubMed search, along with a search of unpublished data from the Pfizer clinical trial database, was used to identify papers describing results from clinical trials of pregabalin in patients with pDPN. Papers were selected for inclusion in the review if they addressed the use of pregabalin in the context of a head-to-head treatment comparison, use in refractory patients, or as part of combination therapy. A discussion of pregabalin dosing and adverse events is also presented. There is some difference with respect to the maximum approved dose of pregabalin for the treatment of pDPN in the United States (300 mg/day) and Euro...Continue Reading

References

May 27, 2003·Diabetes Care·Adam GordoisJanet Ash Tobian
Apr 12, 2005·The Journal of Pain : Official Journal of the American Pain Society·Ralph W RichterLloyd E Knapp
Jun 15, 2007·Journal of Occupational and Environmental Medicine·Walter F StewartNancy A Brandenburg
Oct 17, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Amy M BarrettAmy S Chappell
Jan 24, 2008·Pain Practice : the Official Journal of World Institute of Pain·Alesia SadoskyMarcie Strauss
Mar 19, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Brett R StaceyTeresa Griesing
May 8, 2009·Current Medical Research and Opinion·Debra P RitzwollerAlesia Sadosky
Oct 27, 2009·The Journal of Pain : Official Journal of the American Pain Society·Robert H DworkinSissi V Pham
Nov 11, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·D BansalP Dutta
Dec 8, 2009·The Journal of Pain : Official Journal of the American Pain Society·Che S ZinBrendan J Moore
Dec 22, 2009·Central Nervous System Agents in Medicinal Chemistry·Jan H Vranken
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N AttalT Nurmikko
Sep 8, 2010·Clinical Pharmacokinetics·Howard N BockbraderPaula Burger
Nov 6, 2010·The Journal of Clinical Endocrinology and Metabolism·Aaron Vinik
Nov 23, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marco daCosta DiBonaventuraAshish V Joshi
Jun 23, 2011·Diabetes/metabolism Research and Reviews·S TesfayeUNKNOWN Toronto Expert Panel on Diabetic Neuropathy
Apr 4, 2012·Expert Opinion on Drug Safety·Cory Toth
Apr 13, 2012·Current Medical Research and Opinion·Javier CabreraAndrew Clair
Sep 13, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Setsuro OgawaMakoto Suzuki
Mar 29, 2013·Pain Practice : the Official Journal of World Institute of Pain·Sonya J SnedecorMarc Botteman
Aug 21, 2013·World Journal of Diabetes·Shafina Sachedina, Cory Toth
Dec 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Stephen S JohnstonStuart L Silverman
Dec 18, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Aaron VinikRaymond Cheung

❮ Previous
Next ❯

Citations

Feb 11, 2020·Drugs·Uazman AlamSolomon Tesfaye
Apr 4, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P CiaramitaroUNKNOWN Neuropathic Pain Special Interest Group of the Italian Neurological Society
May 1, 2020·Frontiers in Cellular Neuroscience·Sascha R A AllesTerrance P Snutch
Oct 14, 2020·Journal of Cellular and Molecular Medicine·Tingting ZhaoJinfei Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.