PMID: 14110756Dec 1, 1963Paper

PREGANGLIONIC AND POSTGANGLIONIC STIMULATION OF THE GUINEA-PIG ISOLATED VAS DEFERENS PREPARATION

British Journal of Pharmacology and Chemotherapy
A T Birmingham, A B WILSON

Abstract

The isolated vas deferens of the guinea-pig contracted when stimulated transmurally with parallel wire electrodes. These contractions persisted in concentrations of hexamethonium, pentolinium, nicotine and mecamylamine which at the same time abolished the responses to hypogastric nerve stimulation. Procaine and lignocaine in local anaesthetic concentrations abolished the responses to transmural stimulation but potentiated the contractions produced by added noradrenaline. Guanethidine and bretylium in concentrations specific for adrenergic neurone blockade abolished the contractions due to transmural stimulation without impairing the responses of the muscle to added noradrenaline or acetylcholine. In contrast, high concentrations of the adrenergic-blocking agents phentolamine and dihydroergotamine were needed to block the contractions due to transmural stimulation; these concentrations also blocked the response to added noradrenaline but simultaneously reduced the responses to added acetylcholine or potassium chloride. Preparations from guinea-pigs previously treated with reserpine at first responded normally to transmural stimulation; thereafter the contractions diminished progressively but were never abolished. Hyoscine and at...Continue Reading

References

Apr 1, 1961·British Journal of Pharmacology and Chemotherapy·S HUKOVIC
Apr 1, 1962·British Journal of Pharmacology and Chemotherapy·M D DAY
Apr 1, 1963·British Journal of Pharmacology and Chemotherapy·P OHLIN, B C STROMBLAD
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·G A BENTLEY, J R SABINE
Dec 1, 1960·British Journal of Pharmacology and Chemotherapy·H BoydM J Rand

❮ Previous
Next ❯

Citations

Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·J B Furness, T Iwayama
Apr 8, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·C OWMAN, N O SJOESTRAND
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·J KnollE S Vizi
Jun 1, 1986·Pflügers Archiv : European journal of physiology·M Wakui, Y Fukushi
Mar 16, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Jaramillo
Dec 1, 1969·European Journal of Pharmacology·T C Chou, C Y Lee
Jan 1, 1972·European Journal of Pharmacology·C Y Chiou
Mar 1, 1973·European Journal of Pharmacology·R M Wadsworth
Apr 1, 1976·European Journal of Pharmacology·K GotoY Kasuya
Jan 5, 1981·European Journal of Pharmacology·J S FedanD P Westfall
Sep 1, 1969·International Journal of Neuropharmacology·F ClementiP Mantegazza
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·A Anadón, M R Martinez-Larrañaga
Nov 1, 2001·Journal of Pharmacological and Toxicological Methods·T D Westfall, D P Westfall
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·V H MorgenrothR H Roth
Jun 1, 1979·Anaesthesia·P J Taylor, T E Healy
May 1, 1979·Clinical and Experimental Pharmacology & Physiology·F M Tayo
Dec 1, 1972·British Journal of Urology·C C SchulmanS Boyarsky
Aug 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H Nakanishi, C Wood
Dec 1, 1964·British Journal of Pharmacology and Chemotherapy·D DELLABELLAM PRETI
Jun 1, 1965·British Journal of Pharmacology and Chemotherapy·K P BHARGAVAS S PARMAR
Jun 1, 1965·British Journal of Pharmacology and Chemotherapy·F F VINCENZI, T C WEST
Dec 1, 1965·British Journal of Pharmacology and Chemotherapy·C C Chang, J C Chang
Feb 1, 1965·British Journal of Pharmacology and Chemotherapy·B J LARGE
Oct 1, 1966·British Journal of Pharmacology and Chemotherapy·E R Clark, I E Hughes
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·J D Graham, A L Katib H
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·J D GrahamT L Spriggs
May 1, 1968·British Journal of Pharmacology and Chemotherapy·D A Westwood, B C Whaler
Dec 1, 1970·British Journal of Pharmacology·M C Boadle-BiberR H Roth
May 1, 1972·British Journal of Pharmacology·M Spedding, D F Weetman
Oct 1, 1974·British Journal of Pharmacology·J F Gerkens
Mar 1, 1975·British Journal of Pharmacology·M E Jones, T L Spriggs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.