Pregestational overweight and obesity are associated with differences in gut microbiota composition and systemic inflammation in the third trimester

PloS One
María Florencia ZacaríasSeppo Salminen

Abstract

The obesity epidemic is a global challenge, and the velocity of propagation is high in the population at reproductive age. Overweight and obesity during pregnancy have been associated with high birth weight and an increased risk of childhood obesity, reinforcing the risk of other non-communicable diseases. Obesity involves chronic low-grade systemic inflammation. New biomarkers for early detection of obesity risk are urgently required. The aim of this study was to identify the connection between pregestational BMI (pre-BMI) status and inflammatory biomarkers during the third trimester of pregnancy and their association with intestinal microbiota composition. Fifty-four pregnant women were classified according to pre-pregnancy BMI as normoweight, overweight, or obese. Weight gain, inflammatory biomarkers (hs_CRP, haptoglobin, and suPAR), and microbiota composition were assessed during the third trimester. A significant lower weight gain for obese mothers and a positive correlation between pre-BMI and inflammatory biomarkers were detected (Spearman's correlation). Haptoglobin levels were significantly higher in overweight and obese mothers. Higher Firmicutes levels and a higher ratio Firmicutes/Bacteroidetes were observed in the ...Continue Reading

References

Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Jane E RamsayNaveed Sattar
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·C ChielliniM Maffei
Nov 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luís BeloIrene Rebelo
May 20, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Isaac K Quaye
Oct 10, 2008·The American Journal of Clinical Nutrition·Maria Carmen ColladoSeppo Salminen
Nov 20, 2008·The British Journal of Nutrition·Kirsi LaitinenUNKNOWN Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota Group
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Husen ZhangRosa Krajmalnik-Brown
Jun 6, 2009·Obesity·Andreas SchwiertzPhilip D Hardt
Apr 7, 2010·Science Translational Medicine·Peter J TurnbaughJeffrey I Gordon
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Sep 21, 2010·Journal of Microbiological Methods·Lotta NylundReetta Satokari
Aug 11, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M MillionD Raoult
Feb 22, 2012·American Journal of Obstetrics and Gynecology·Tracey L WeissgerberRobin E Gandley
Jul 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Nancy OddenLars Mørkrid
Mar 19, 2013·Obesity·Camilla M FriisTore Henriksen
Aug 30, 2013·Nature·Aurélie CotillardStanislav Dusko Ehrlich
Jul 24, 2014·Cancer Causes & Control : CCC·Bo ZhouYingying Xing
Aug 1, 2015·PloS One·Hae-Jin HuSeung-Hak Cho
Sep 12, 2015·Circulation Research·Jingyuan FuAlexandra Zhernakova
Feb 10, 2016·Journal of Clinical Laboratory Analysis·Mahmoud EbrahimiMajid Ghayour-Mobarhan
May 10, 2016·Molecular Nutrition & Food Research·Izaskun Garcia-Mantrana, Maria Carmen Collado
Jun 12, 2016·Seminars in Fetal & Neonatal Medicine·Carlos Gomez-GallegoMaría Carmen Collado
Jul 30, 2016·Frontiers in Microbiology·Meital Nuriel-OhayonOmry Koren
Aug 9, 2016·Journal of Clinical Biochemistry and Nutrition·Akira AndohToshio Kobayashi
Feb 23, 2017·Expert Review of Proteomics·Aggeliki KolialexiNikolas Papantoniou
Mar 23, 2017·American Journal of Reproductive Immunology : AJRI·Karen Priscilla Tezotto PendeloskiSilvia Daher

❮ Previous
Next ❯

Citations

Mar 7, 2020·International Journal of Environmental Research and Public Health·Mei-Hsin HsuLi-Tung Huang
Feb 14, 2020·FEMS Microbiology Letters·Shreyas V KumbhareYogesh S Shouche
Oct 23, 2019·Annual Review of Public Health·Audrey RensonJennifer B Dowd
Apr 10, 2020·The Journal of Nutrition·Kate J Claycombe-LarsonJames N Roemmich
Jul 13, 2019·Frontiers in Cellular and Infection Microbiology·Li-Juan LvAi-Hua Yin
Aug 23, 2019·Annual Review of Nutrition·Carlos Gómez-GallegoM Carmen Collado
Sep 11, 2019·The American Journal of Clinical Nutrition·Evelyn Jantscher-KrennMireille N M van Poppel
Jun 25, 2019·Annals of Nutrition & Metabolism·Martin G CodagnoneJohn F Cryan

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT00167700

Software Mentioned

Calypso
GraphPad
GraphPad Prism
QIIME

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Shlomit Riskin-MashiahRon Auslander
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Tripop LertbunnaphongVitaya Titapant
© 2022 Meta ULC. All rights reserved