Pregnancies and births after oocyte cryopreservation

Fertility and Sterility
A BoriniC Flamigni

Abstract

To determine the potential of oocyte cryopreservation techniques. Retrospective data analysis. A tertiary infertility center. Sixty-eight patients (29 to 37 years of age) undergoing assisted reproduction procedures for infertility problems. Oocytes from women treated for infertility were cryopreserved with a slow cooling/rapid thawing protocol in which 1,2 propanediol and sucrose were used as cryoprotectants. Eighty-six thawing cycles were performed. Rates of survival after thawing, fertilization after intracytoplasmic sperm injection, cleavage, implantation, and pregnancy. We treated 68 patients through 86 thawing cycles. Seven hundred thirty-seven oocytes were thawed, and 59 transfer cycles were performed. The survival rate was 37%. The fertilization and cleavage rates were 45.4% and 86.3%, respectively. A total of 15 clinical pregnancies were achieved with pregnancy rates of 25.4% per transfer and 22% per patient. There were three miscarriages, resulting in an abortion rate of 20%. Seventeen of the 104 transferred embryos implanted, corresponding to an implantation rate of 16.4%. Thirteen babies were born, 8 females and 5 males. Statistically significant results were obtained for fertilization, cleavage, and pregnancy rates....Continue Reading

Associated Clinical Trials

References

Dec 22, 1999·Human Reproduction·L KuleshovaA Trounson
Mar 3, 2001·Human Reproduction·R FabbriC Flamigni
Oct 27, 2001·Seminars in Reproductive Medicine·E Porcu
Nov 29, 2002·Human Reproduction·Carlos J QuintansR Sergio Pasqualini
May 30, 2003·Human Reproduction·Jeffrey BoldtDavid McLaughlin
Jul 2, 2003·Human Reproduction·N FosasS Marina

❮ Previous
Next ❯

Citations

Feb 9, 2010·Journal of Assisted Reproduction and Genetics·Nicole NoyesZsolt Peter Nagy
Feb 24, 2010·Journal of Assisted Reproduction and Genetics·Giovanni CoticchioStefania A Nottola
Dec 25, 2012·Journal of Assisted Reproduction and Genetics·Sandra SanfilippoFlorence Brugnon
Apr 30, 2009·Reproductive Biomedicine Online·Nicoletta TarozziAndrea Borini
Jun 24, 2006·Reproductive Biomedicine Online·S ChamayouA Guglielmino
Jun 14, 2005·Reproductive Biomedicine Online·S J Paynter
Jul 8, 2005·The New England Journal of Medicine·Rogerio A Lobo
Feb 10, 2011·Human Reproduction·Javier I GarcíaLuis Noriega-Hoces
Aug 14, 2012·Human Reproduction·Katherine E Dillon, Autumn M Fiester
Jun 1, 2006·Current Opinion in Obstetrics & Gynecology·Eleonora Porcu, Stefano Venturoli
Jan 7, 2009·Current Opinion in Obstetrics & Gynecology·Lara Dunn, Kevin R Fox
Nov 5, 2010·Clinical Obstetrics and Gynecology·Andrea Borini, Veronica Bianchi
Jan 31, 2014·Journal of Assisted Reproduction and Genetics·Ri-Cheng ChianYi-Ran Li
Apr 25, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Soyoung BangHyunjung Jade Lim
Dec 23, 2011·ISRN Obstetrics and Gynecology·Jacira Ribeiro Campos, Ana Carolina Japur de Sá Rosa-E-Silva
Oct 12, 2013·Journal of Assisted Reproduction and Genetics·Fausta BrambillascaRubens Fadini
Dec 18, 2015·Journal of Assisted Reproduction and Genetics·Paolo Emanuele P E Levi-SettiGiulia Scaravelli
Sep 6, 2011·Reproductive Biomedicine Online·Lucia De Santis, Giovanni Coticchio
Jul 19, 2011·Reproductive Biomedicine Online·Gary D SmithPaulo Serafini
Feb 26, 2016·Reproductive Biomedicine Online·Sayyed Morteza Hosseini, Mohammad Hossein Nasr-Esfahani
Jan 18, 2011·Reproductive Biomedicine Online·Lucia De Santis, Giovanni Coticchio
Jul 12, 2008·Reproductive Biomedicine Online·Alessandra CamboniAnne Van Langendonckt
Aug 17, 2005·Reproductive Biomedicine Online·Lucia De SantisGiovanni Coticchio
Sep 26, 2009·Reproductive Biomedicine Online·Yunxia CaoLin Cong
Jul 12, 2007·Reproductive Biomedicine Online·G CoticchioA Borini
Sep 21, 2006·Reproductive Biomedicine Online·N KoutlakiS Al-Hasani
Jan 6, 2010·Fertility and Sterility·Andrea BoriniGiulia Scaravelli
Mar 28, 2009·Fertility and Sterility·Ching-Chien ChangZsolt Peter Nagy
Sep 26, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·A Borini
Aug 21, 2007·Fertility and Sterility·Ester Polak de FriedJosé Cibelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.