Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS).

Journal of the National Cancer Institute
Nadine AndrieuIBCCS Collaborators Group

Abstract

Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1, regulates normal cell differentiation. Because mammary gland cells divide and differentiate during pregnancy, reproductive factors may influence breast cancer risk in BRCA1/2 mutation carriers differently than they do in noncarriers. We performed a retrospective cohort study of 1601 women in the International BRCA1/2 Carrier Cohort Study cohort, all of whom carried a mutation in BRCA1 or BRCA2. Information on reproductive factors was obtained from a questionnaire. At the time of interview 853 subjects were classified with breast cancer. Data were analyzed by using a weighted cohort approach. All statistical tests were two-sided. There was no statistically significant difference in the risk of breast cancer between parous and nulliparous women. Among parous women, an increasing number of full-term pregnancies was associated with a statistically significant decrease in the risk of breast cancer (Ptrend = .008); risk was reduced by 14% (95% confidence interval [CI] = 6% to 22%) for each additional birth. This association was the same for carriers...Continue Reading

References

Jan 1, 1992·Breast Cancer Research and Treatment·J RussoI H Russo
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·D R PathakR J Lipnick
Jan 1, 1982·Breast Cancer Research and Treatment·J RussoI H Russo
Apr 24, 1993·Lancet·V Beral, G Reeves
Jul 7, 1994·The New England Journal of Medicine·M LambeH O Adami
Jan 1, 1993·Epidemiologic Reviews·J L KelseyE M John
Jan 1, 1993·Epidemiologic Reviews·J L Kelsey, P L Horn-Ross
Dec 20, 1995·International Journal of Cancer. Journal International Du Cancer·S A NarodH Lynch
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·J Chang-ClaudeU Hamann
Mar 16, 2001·Breast Cancer Research : BCR·D F Easton
May 18, 2001·Nature·B A Ponder
Feb 8, 2002·Cell·Ashok R Venkitaraman
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Laufey TryggvadóttirTrausti Sigurvinsson
Apr 20, 2002·Epidemiology·Patricia HartgeJeffery P Struewing
Aug 22, 2002·Journal of the National Cancer Institute·Colin B Begg
Feb 1, 2003·Breast Cancer Research : BCR·Christopher R Mueller, Calvin D Roskelley
Aug 21, 2003·Breast Cancer Research : BCR·Laufey TryggvadottirJorunn E Eyfjord
Jun 17, 2004·Molecular and Cellular Biology·Mahnaz RazandiEllis R Levin
Jul 22, 2004·Journal of the National Cancer Institute·H JernströmS A Narod
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Carey A CullinaneSteven A Narod
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil R LakhaniUNKNOWN Breast Cancer Linkage Consortium
Sep 6, 2005·Journal of Medical Genetics·C J van AsperenUNKNOWN Netherlands Collaborative Group on Hereditary Breast Cancer (HEBON)

❮ Previous
Next ❯

Citations

Aug 12, 2009·Archives of Internal Medicine·Alison M StuebeKarin B Michels
Jan 10, 2008·JAMA : the Journal of the American Medical Association·Colin B BeggJonine L Bernstein
May 18, 2010·Wiener medizinische Wochenschrift·Gunda PristauzEdgar Petru
Jan 25, 2007·Breast Cancer Research and Treatment·Joanne KotsopoulosC Bellati
Apr 11, 2009·Breast Cancer Research and Treatment·Anna JakubowskaUte Hamann
Oct 24, 2009·Breast Cancer Research and Treatment·Gitana Maria AcetoErnesto Jorge Podestà
Mar 24, 2010·Breast Cancer Research and Treatment·Patricia G MoormanJoellen M Schildkraut
Jun 24, 2011·Breast Cancer Research and Treatment·Olivia PaganiUNKNOWN North American Breast Cancer Group Endocrine Working Group
Apr 22, 2009·Journal of Mammary Gland Biology and Neoplasia·Traci R LyonsVirginia F Borges
Jul 20, 2007·Current Treatment Options in Oncology·Diana S RosmanBoris Pasche
Apr 7, 2010·Medical Oncology·K O Hajian-Tilaki, T Kaveh-Ahangar
Jan 27, 2011·European Journal of Human Genetics : EJHG·Claire Julian-ReynierCatherine Noguès
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J BalmañaUNKNOWN ESMO Guidelines Working Group
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G PentheroudakisUNKNOWN ESMO Guidelines Working Group
Feb 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Warner
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J BalmañaUNKNOWN ESMO Guidelines Working Group
Jan 29, 2009·Human Reproduction Update·M HickeyM Friedlander
Jul 12, 2007·Journal of the National Cancer Institute·Laetitia Huiart, Marie-Pierre Sylvestre
May 1, 2013·Journal of the National Cancer Institute·Nasim MavaddatUNKNOWN EMBRACE
Aug 19, 2007·The Journal of Perinatal & Neonatal Nursing·Barbara Camune, Elizabeth Gabzdyl
Mar 11, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nancie PetrucelliGerald L Feldman
Jun 12, 2008·Annual Review of Genomics and Human Genetics·Clare Turnbull, Nazneen Rahman
May 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joanne KotsopoulosSteven A Narod
Dec 26, 2006·Breast Cancer Research : BCR·Antonis C AntoniouD Gareth Evans
Sep 25, 2007·Breast Cancer Research : BCR·D Gareth R Evans, Anthony Howell
Aug 20, 2008·Breast Cancer Research : BCR·Timothy R Rebbeck, Susan M Domchek
Jan 16, 2009·Breast Cancer Research : BCR·Diana M Eccles
Mar 13, 2012·Breast Cancer Research : BCR·Joanne KotsopoulosUNKNOWN Hereditary Breast Cancer Clinical Study Group
Sep 6, 2012·Endocrine Reviews·Bramanandam ManavathiRakesh Kumar
Mar 8, 2012·Annals of Surgical Oncology·David Euhus
Dec 15, 2010·The Oncologist·Jennifer K Litton, Richard L Theriault
Sep 26, 2012·The Oncologist·Kenny A Rodriguez-Wallberg, Kutluk Oktay
Jan 31, 2014·Breast Cancer Research and Treatment·Kristin N AndersonMaria Elena Martinez
May 29, 2012·Familial Cancer·Monique A de BruinAllison W Kurian
May 16, 2014·Journal of the National Cancer Institute·Tara M FriebelTimothy R Rebbeck
Apr 17, 2009·Breast Cancer Research and Treatment·Roger L MilneJavier Benítez
Aug 15, 2009·Breast Cancer Research and Treatment·Anouk PijpeMatti A Rookus
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Fariba SalehiKristan J Aronson
Aug 24, 2010·Breast Cancer Research and Treatment·Peggy MandersMatti A Rookus
Feb 7, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Josep M SabateEnrique Lerma
Sep 1, 2006·Women's Health·Olivia Pagani, Aron Goldhirsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Carey A CullinaneSteven A Narod
Journal of the National Cancer Institute
H JernströmSteven A Narod
Breast Cancer Research : BCR
Antonis C AntoniouD Gareth Evans
© 2022 Meta ULC. All rights reserved