Pregnancy After Breast Cancer in Patients With Germline BRCA Mutations.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Matteo LambertiniHatem A Azim

Abstract

Young women with germline BRCA mutations have unique reproductive challenges. Pregnancy after breast cancer does not increase the risk of recurrence; however, very limited data are available in patients with BRCA mutations. This study investigated the impact of pregnancy on breast cancer outcomes in patients with germline BRCA mutations. This is an international, multicenter, hospital-based, retrospective cohort study. Eligible patients were diagnosed between January 2000 and December 2012 with invasive early breast cancer at age ≤ 40 years and harbored deleterious germline BRCA mutations. Primary end points were pregnancy rate, and disease-free survival (DFS) between patients with and without a pregnancy after breast cancer. Pregnancy outcomes and overall survival (OS) were secondary end points. Survival analyses were adjusted for guarantee-time bias controlling for known prognostic factors. Of 1,252 patients with germline BRCA mutations (BRCA1, 811 patients; BRCA2, 430 patients; BRCA1/2, 11 patients) included, 195 had at least 1 pregnancy after breast cancer (pregnancy rate at 10 years, 19%; 95% CI, 17% to 22%). Induced abortions and miscarriages occurred in 16 (8.2%) and 20 (10.3%) patients, respectively. Among the 150 patie...Continue Reading

Associated Clinical Trials

Nov 9, 2011·Ann H. Partridge, MD, MPH

References

Feb 1, 2003·Breast Cancer Research : BCR·Christopher R Mueller, Calvin D Roskelley
Sep 9, 2010·Advances in Experimental Medicine and Biology·Helen DolkEster Garne
Oct 15, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hatem A AzimFedro A Peccatori
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Hanne StensheimSophie D Fosså
Aug 9, 2012·Breast Care·Olivia Pagani, Hatem Azim
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hatem A AzimFedro A Peccatori
Jul 3, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F A PeccatoriUNKNOWN ESMO Guidelines Working Group
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anita Giobbie-HurderMeredith M Regan
Oct 19, 2013·Breast Cancer Research and Treatment·Adriana ValentiniUNKNOWN Hereditary Breast Cancer Clinical Study Group
Feb 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn J RuddyAnn H Partridge
May 16, 2014·Journal of the National Cancer Institute·Tara M FriebelTimothy R Rebbeck
Jun 6, 2014·Obstetrics and Gynecology·Audrey J GaskinsJorge E Chavarro
Feb 13, 2016·JAMA Oncology·Shoshana M RosenbergAnn H Partridge
Sep 25, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Paluch-ShimonUNKNOWN ESMO Guidelines Committee
Mar 10, 2017·JAMA Oncology·Javaid IqbalSteven A Narod
Jul 28, 2017·Cancer Treatment Reviews·Matteo LambertiniIsabelle Demeestere
Oct 19, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LambertiniI Demeestere
Nov 1, 2017·Journal of the National Cancer Institute·Matteo LambertiniHatem A Azim
Mar 9, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anne-Lotte L F van der KooiRichard A Anderson
Mar 23, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Paluch-ShimonO Pagani

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Citations

Sep 22, 2020·Breast Cancer : Basic and Clinical Research·Luca AreccoMatteo Lambertini
Oct 31, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven A Narod, Vasily Giannakeas
Oct 31, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hatem A AzimMatteo Lambertini
Dec 18, 2020·Critical Reviews in Oncology/hematology·Petra VukovićMatteo Lambertini
Jan 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiu-Xian ZhengZhi Chen
Mar 20, 2021·Journal of Assisted Reproduction and Genetics·Mary Kathryn AbelMitchell P Rosen
May 15, 2021·American Society of Clinical Oncology Educational Book·Ines Vaz-LuisVered Stearns
Jul 26, 2021·The Breast : Official Journal of the European Society of Mastology·Laurie Denis-LaroqueChristine Rousset-Jablonski
Jul 2, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matteo LambertiniFedro A Peccatori

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