Pregnancy after cryopreservation of donor oocytes and preimplantation genetic diagnosis of embryos in a patient with ovarian failure

Fertility and Sterility
Kathleen A MillerRichard T Scott

Abstract

To describe the successful use of preimplantation genetic diagnosis to assess the prevalence of meiotic errors after oocyte cryopreservation in an oocyte donation cycle. Case report. Private IVF center. A 42.6-year-old patient with ovarian failure. A donor oocyte IVF cycle with cryopreservation of oocytes followed by thaw, fertilization of oocytes, preimplantation genetic diagnosis for selective aneuploidy, and ET. Preimplantation genetic analysis of chromosomes 13,16,18, 21,22, X, and Y with fluorescence in-situ hybridization. The recipient's initial serum beta-hCG level was 196 mIU/mL 15 days after oocyte retrieval. An initial ultrasound at the sixth week of gestation revealed two gestational sacs. A second ultrasound 1 week later showed a monochorionic twin in sac A and a singleton pregnancy in sac B. Fetal cardiac activity was visualized for all gestations. This case illustrates the feasibility of cryopreservation of donor oocytes combined with preimplantation genetic diagnosis for clinical use in those settings where there may be an increased risk of spindle-related abnormalities.

References

Mar 28, 1987·Lancet·J F van UemN Lang
Oct 3, 1998·Fertility and Sterility·M J TuckerJ B Massey
Dec 16, 1998·Human Reproduction·M J TuckerJ B Massey
Jan 13, 2001·Molecular and Cellular Endocrinology·K Y ChaT K Yoon
Feb 24, 2001·Hospital Medicine·O SalhaA Rutherford
Mar 3, 2001·Human Reproduction·R FabbriC Flamigni

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Citations

Feb 15, 2005·Prenatal Diagnosis
Feb 19, 2009·Journal of Assisted Reproduction and Genetics·Vitaly A Kushnir, John L Frattarelli
Mar 9, 2010·Critical Reviews in Oncology/hematology·Raymond Manohar Anchan, Elizabeth Sarah Ginsburg
Aug 21, 2007·Fertility and Sterility·Ester Polak de FriedJosé Cibelli
Jul 5, 2006·Fertility and Sterility·Kutluk OktayHeejung Bang
Sep 16, 2016·Journal of Assisted Reproduction and Genetics·Natalia Basile, Juan A Garcia-Velasco
Oct 31, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Eleonora PorcuStefano Venturoli
Sep 12, 2007·Human Reproduction Update·Debra A Gook, David H Edgar

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