Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

Journal of Ovarian Research
F FabreguesF Carmona

Abstract

The aim of this report was to describe a case of pregnancy after drug-free in vitro activation (IVA) of follicles and fresh tissue autotransplantation in primary ovarian insufficiency (POI) patient and to review the pertinent literature. We present a case in wich a 32 - years old patient with POI became pregnant after IVA without tissue culture and with ovarian tissue transplantation. We also reviewed the literature using Pubmed database. Pretreatment with estradiol/progesterone stopped the day before surgery. The removal of the ovarian cortex and autotransplantation were performed by laparoscopy in the same surgical act. Ovarian fragments were transplanted in contralateral ovary and peritoneal pocket near to the ovary. Immediately after surgery GnRH agonist together HMG injections started, leading the growth of 3 preovulatory follicles and the retrieval of two mature eggs. After IVF two embryos were transferred and singleton pregnancy was established and currently she is 25 weeks pregnant. A total of 51 patients with POI in whom an in vitro activation of ovarian tissue was performed, were collected from the revieew of the literature. In 29.4% of them, follicular development was obtained and in 4 of them a pregnancy. In all of ...Continue Reading

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Citations

Aug 8, 2020·Endocrine Reviews·Johanne GrosboisIsabelle Demeestere
May 8, 2020·International Journal of Molecular Sciences·Erica SilvestrisAngelo Virgilio Paradiso
Jun 12, 2019·Clinical and Experimental Reproductive Medicine·Hye Nam Lee, Eun Mi Chang
Jun 9, 2020·Molecular Reproduction and Development·Stine A LundingSusanne E Pors
Jan 12, 2021·Climacteric : the Journal of the International Menopause Society·R Rosario, R A Anderson
Jan 24, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Wanxue WangVladimir Isachenko
Mar 16, 2021·Frontiers in Endocrinology·Alba M PolonioSonia Herraiz
May 1, 2021·International Journal of Molecular Sciences·Kim Cat Tuyen Vo, Kazuhiro Kawamura

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