Pregnancy after liver transplantation: report of 8 new cases and review of the literature

Transplant Immunology
Marialuisa Framarino Dei MalatestaRaffaello Cortesini

Abstract

Improved survival and quality of life following liver transplantation are associated with an increased frequency of pregnancies in liver-transplanted women. We investigated the outcome, complications, and management of those pregnancies. We have reviewed the literature and report 8 pregnancies in 6 transplant recipients. Seven pregnancies were completed at 38+/-2 (mean+/-standard deviation) weeks. One miscarriage occurred at week 12. Newborns' weight averaged 2938+/-156 g. Main complications were preeclampsia (n=1) and reversible cholestasis (n=1). Among 285 pregnancies reported in literature, 78+/-20% were successful and the main complications were: preeclampsia (26+/-19%), hypertension (28+/-19%), reversible liver dysfunction (27+/-21%), cesarean delivery (23+/-10%), preterm birth (31+/-28%), small for gestational age infants (23+/-10%), rejection (10+/-7%). Gestational weeks were 36.7+/-1.3, perinatal mortality was 4+/-10%, malformation rate 3%. The rates of both abortions and complications (preeclampsia and/or hypertension) were inversely related to the time interval between transplantation and conception (p<0.05). Abortions occurred more often in recipients whose underlying disease was autoimmune cirrhosis than in recipien...Continue Reading

References

Feb 1, 1990·Transplantation·V ScantleburyT E Starzl
Aug 27, 1996·Transplantation·K MassR M Merion
Feb 1, 1997·Transplantation Proceedings·P PatapisP McMaster
Jan 5, 2001·Annals of Surgery·M F LevyG B Klintmalm
Mar 27, 2001·Transplantation Proceedings·R RaakowP Neuhaus
Jul 13, 2001·American Journal of Surgery·J M RabkinA J Olyaei
Sep 7, 2001·Transplantation·C E GarciaJ Neuberger
Sep 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J PruthiT L Fong
Jan 10, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Adam Morton
Jan 28, 2004·British Journal of Pharmacology·S M GardinerT Bennett
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michiel C WarléHugo W Tilanus

❮ Previous
Next ❯

Citations

Jan 1, 2014·Journal of Medical Case Reports·Antonia WennersIbrahim Alkatout
Jan 3, 2014·Case Reports in Obstetrics and Gynecology·Nina KimmichNicole Ochsenbein-Kölble
Oct 23, 2010·La Presse médicale·Aurélie RevauxGuillaume Ducarme
Sep 27, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Carlo B Ramirez, Cataldo Doria
Nov 28, 2013·World Journal of Gastroenterology : WJG·Ghassan M HammoudJamal A Ibdah
Dec 2, 2011·Journal of Transplantation·Srdjan SasoGiuseppe Del Priore
Jul 21, 2009·Archives of Gynecology and Obstetrics·Hisashi MasuyamaYuji Hiramatsu
Sep 17, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Miroslaw WielgosBronislawa Pietrzak
Jan 12, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Chrysoula Margioula-SiarkouDavid Rousso
Feb 3, 2016·The American Journal of Gastroenterology·Tram T TranNancy S Reau
Feb 11, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A-C Goarin, L Homer
Dec 8, 2007·Seminars in Perinatology·Clarissa Bonanno, Lorna Dove
Aug 19, 2007·Transplantation Proceedings·M Framarino Dei MalatestaP Berloco
Jul 4, 2007·Clinics in Liver Disease·Lawrence U Liu, Thomas D Schiano
Jan 19, 2010·ANZ Journal of Surgery·Abdelbasit Elsayed Ali, William David Andrew Ford
Nov 26, 2015·Critical Care Clinics·Stephen J Bacak, Loralei L Thornburg
Oct 19, 2011·Pediatric Transplantation·C W N SpearmanA J W Millar
Mar 13, 2012·Pediatric Transplantation·Çiğdem EcevitSema Aydoğdu
Feb 22, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Neha A DeshpandeDorry L Segev
Jan 31, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shoji KuboUNKNOWN Japanese Liver Transplantation Society
Aug 27, 2015·Transplantation·Elena OrtonaMarialuisa Framarino-Dei-Malatesta
Mar 20, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Žana ŽegaracVesna Čolić Cvrlje
Apr 6, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sarah GhazaliHaim A Abenhaim
Jun 9, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Women in Hepatology Group, UNKNOWN Italian Association for the Study of the Liver (AISF)
Aug 9, 2016·Transplantation Proceedings·A MadejM Wielgos
Sep 1, 2009·Transplantation Proceedings·V NicovaniL Pérez
Dec 6, 2011·Reproductive Sciences·Srdjan SasoGiuseppe Del Priore
Nov 22, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Joanna Schreiber-ZamoraBozena Kociszewska-Najman
Jul 6, 2018·The Journal of Obstetrics and Gynaecology Research·Gurcan TurkyilmazAtil Yuksel
Dec 4, 2019·Clinical Obstetrics and Gynecology·Catherine M Albright, Emily E Fay
Apr 12, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gebhard WagenerJean Emond
Oct 23, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Fabrizio ZulloVincenzo Berghella
Jan 26, 2013·Transplantation·Bozena Kociszewska-NajmanMiroslaw Wielgos
Feb 18, 2017·World Journal of Gastroenterology : WJG·Hisanobu HigashiYuko Kitagawa
Jul 7, 2009·Arquivos De Gastroenterologia·Mônica Beatriz ParolinMelina Pampuch
Mar 4, 2021·The American Journal of Gastroenterology·Nelson ValentinIlan Weisberg
Sep 15, 2020·Transplant Immunology·Rui ZhangKun Yu
Jul 11, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Aneesh KallapurYalda Afshar
Jul 9, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ella J MarsonSteven A White

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Related Papers

Obstetrics and Gynecology
Sandor NagyVeronica Gomez-Lobo
Liver International : Official Journal of the International Association for the Study of the Liver
Bijal SurtiSammy Saab
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Vimala ChristopherMichael A Heneghan
Transplantation
Velma ScantleburyT E Starzl
© 2022 Meta ULC. All rights reserved