Pregnancy allows the transfer and differentiation of fetal lymphoid progenitors into functional T and B cells in mothers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kiarash KhosrotehraniSélim Aractingi

Abstract

T lymphocytes of fetal origin found in maternal circulation after gestation have been reported as a possible cause for autoimmune diseases. During gestation, mothers acquire CD34+CD38+ cells of fetal origin that persist decades. In this study, we asked whether fetal T and B cells could develop from these progenitors in the maternal thymus and bone marrow during and after gestation. RAG-/--deficient female mice (Ly5.2) were mated to congenic wild-type Ly5.1 mice (RAG+/+). Fetal double-positive T cells (CD4+CD8+) with characteristic TCR and IL-7R expression patterns could be recovered in maternal thymus during the resulting pregnancies. We made similar observations in the thymus of immunocompetent mothers. Such phenomenon was observed overall in 12 of 68 tested mice compared with 0 of 51 controls (p=0.001). T cells could also be found in maternal spleen and produced IFN-gamma in the presence of an allogenic or an Ag-specific stimulus. Similarly, CD19+IgM+ fetal B cells as well as plasma Igs could be found in maternal RAG-/- bone marrow and spleen after similar matings. Our results suggest that during gestation mothers acquire fetal lymphoid progenitors that develop into functional T cells. This fetal cell microchimerism may have ...Continue Reading

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Citations

Jul 12, 2008·Human Reproduction·Margarida Avo SantosNicholas M Fisk
Jun 3, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Olivier ParantKiarash Khosrotehrani
Dec 7, 2010·Chimerism·Partha Dutta, William J Burlingham
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Aug 17, 2010·Stem Cells and Development·Xiao Xia ZengGerald Udolph
May 26, 2012·Chimerism·Dany NassarSelim Aractingi
Sep 30, 2020·Annals of the New York Academy of Sciences·Sangeetha Vadakke-Madathil, Hina W Chaudhry
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Jun 11, 2009·Current Opinion in Organ Transplantation·Partha Dutta, William J Burlingham
Sep 16, 2008·International Journal of Cancer. Journal International Du Cancer·Sau Nguyen HuuSélim Aractingi
Aug 27, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Michele LeducKiarash Khosrotehrani
Nov 12, 2009·Future Oncology·Kiarash Khosrotehrani, Selim Aractingi
Nov 17, 2009·Expert Reviews in Molecular Medicine·David M LissauerMark D Kilby
Oct 10, 2012·Reproduction, Fertility, and Development·María E CortinaSilvia Miranda
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Jan 17, 2009·The American Journal of Pathology·Sau Nguyen HuuSelim Aractingi
Feb 26, 2013·Journal of Reproductive Immunology·E SeppanenK Khosrotehrani

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