Pregnancy Alters Renal and Blood Burden of Mercury in Females.

Biological Trace Element Research
Sarah E OrrChristy C Bridges

Abstract

Methylmercury (CH3Hg+), a common environmental toxicant, has serious detrimental effects in numerous organ systems. We hypothesize that a significant physiological change, like pregnancy, can alter the disposition and accumulation of mercury. To test this hypothesis, pregnant and non-pregnant female Wistar rats were exposed orally to CH3Hg+. The amount of mercury in blood and total renal mass was significantly lower in pregnant rats than in non-pregnant rats. This finding may be due to expansion of plasma volume in pregnant rats and dilution of mercury, leading to lower levels of mercury in maternal blood and kidneys.

References

Jan 1, 1993·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·C N OngP Liouw
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Christy C BridgesRudolfs K Zalups
Sep 26, 2008·Environmental Research·Natalie K Karouna-RenierGlenn T Ross
Dec 6, 2008·Epidemiology·Takashi YorifujiMasazumi Harada
Dec 10, 2008·Toxicology and Applied Pharmacology·Rudolfs K Zalups, Christy C Bridges
Oct 13, 2012·Reproductive Toxicology·Christy C BridgesRudolfs K Zalups
May 2, 2014·International Journal of Hygiene and Environmental Health·Roxanne KarimiJaymie R Meliker
Sep 1, 2015·Journal of Community Health·Rebecca MonasteroJaymie Meliker
Oct 22, 2016·American Journal of Physiology. Renal Physiology·Crystal A WestChris Baylis

❮ Previous
Next ❯

Citations

May 29, 2019·Basic & Clinical Pharmacology & Toxicology·Geir BjørklundJan Aaseth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.