PMID: 9166333May 1, 1997Paper

Pregnancy and delivery in a patient with mutilating dystrophic epidermolysis bullosa (Hallopeau-Siemens type)

Obstetrics and Gynecology
U BüscherJ W Dudenhausen

Abstract

Epidermolysis bullosa dystrophica of the mutilating Hallopeau-Siemens type is a rare inherited skin disease. Those afflicted have blisters and pronounced scarring of skin and mucous membranes after minor trauma. Pregnancies are very rare in affected women. A 24-year-old woman, gravida 1, with a severe form of the Hallopeau-Siemens type was monitored closely during pregnancy. The patient spontaneously delivered a healthy female neonate at term. Episiotomy wound healing was uncomplicated. Seven months later, she returned in her second pregnancy, which was complicated by mild anemia and polyhydramnios from possible gestational-onset diabetes mellitus. Again, vaginal delivery of a healthy neonate was performed at term. We did not observe pregnancy-induced exacerbations of the skin disease. Women with epidermolysis bullosa dystrophica of the Hallopeau-Siemens type may decide to have children after careful evaluation of the degree of impairment and a thorough explanation of the risks associated with pregnancy and delivery. Close monitoring of the pregnant patient is important. Vaginal delivery should be the first choice. Breast-feeding is difficult, but not contraindicated.

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Citations

Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S BiancaG Ettore
Feb 8, 2007·Gynecologic and Obstetric Investigation·Shusaku HayashiYuji Murata
Mar 1, 2008·International Journal of Obstetric Anesthesia·M S BalochG O'Sullivan
Oct 20, 2011·Clinical and Experimental Dermatology·T HanafusaI Katayama
Jun 1, 2011·The British Journal of Dermatology·S D ChoiD F Murrell
Mar 1, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E OzkayaT Kucukozkan
Sep 1, 2010·Obstetric Medicine·L A BoltA Shennan
Oct 24, 2021·The British Journal of Dermatology·D T GreenblattJ E Mellerio

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