Pregnancy and epilepsy: a retrospective study of 151 pregnancies

Acta Neurologica Scandinavica
A SabersH Winkel

Abstract

We studied the course of pregnancy in women with epilepsy to identify possible risk factors which might complicate the epilepsies and pregnancy outcomes. Data were collected retrospectively from the records of 151 pregnancies in 124 women with epilepsy from 1978-1992. Epilepsy variables were compared with that of non-pregnant women with epilepsy matched for age. Obstetric and neonatal variables were compared with those of all deliveries in the same unit from 1979-1992 (n=38,983). Pregnancy among patients with epilepsy was more likely to occur in women with relatively mild epilepsy. In 12% of the pregnancies, the women were untreated while 71% were on monotherapy. Twenty-one percent had increased seizure frequency during the pregnancy. Perinatal deaths among newborns of epileptic mothers (1.3%) was more frequent but not significantly increased compared to the background population of 0.5% (95% CI 0.2-4.7). A total of 5.3% had congenital malformations compared to 1.5% in the controls (95% CI 2.3-10.3). No neural tube defects were observed. Maternal treatment with phenytoin was significantly related to the occurrence of congenital malformations, P=0.04. Most women with epilepsy have an uncomplicated pregnancy and normal healthy of...Continue Reading

References

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Citations

Dec 10, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Merih CetinkayaNilgün Köksal
Jan 1, 2008·Expert Review of Clinical Pharmacology·Anne Sabers, Vaiva Petrenaite
Feb 24, 2001·The Australian & New Zealand Journal of Obstetrics & Gynaecology·T J O'Brien, F J Vajda
Feb 9, 2000·Clinical Genetics·J E Polifka, J M Friedman
Oct 11, 2005·Critical Care Medicine·Dilip R Karnad, Kalpalatha K Guntupalli
Dec 5, 2003·Acta Neurologica Scandinavica·A SabersA Mouritzen Dam
Jan 15, 2009·Epilepsia·Umberto AgugliaAlberto Verrotti
Jun 6, 2009·Epilepsia·Anne Sabers, Vaiva Petrenaite
Jul 30, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Angela La NeveLuigi M Specchio
Jul 20, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·C L HvasM Dam
Jun 30, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Prameela KarimiJeffrey M Perlman
May 15, 2021·Neurology and Therapy·Mervyn J Eadie

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