Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study

BJOG : an International Journal of Obstetrics and Gynaecology
T S LøvvikE Vanky

Abstract

To investigate pregnancy and perinatal outcomes in twin births among women with and without polycystic ovary syndrome (PCOS) diagnosis. Population-based cohort study. Sweden. We identified 20,965 women with twin births between 1995 and 2009 of whom 226 had a PCOS diagnosis through linkage between the Swedish Medical Birth Register and the Swedish National Patient Register. Calculating risk ratios (RR) with 95% confidence intervals (CI) using a log-binomial regression model and hazard ratios (HR) with 95% CI for preterm birth. Preterm birth, low birthweight, caesarean section, pre-eclampsia, Apgar score <7 at 5 minutes and perinatal mortality. PCOS diagnosis in twin pregnancy was associated with increased risk of preterm delivery (51% versus 43%, RR 1.18 [95% CI 1.03-1.37]), particularly spontaneous preterm delivery (37% versus 28%; RR 1.30 [95% CI 1.09-1.55]) and very preterm birth (<32 weeks) (14% versus 8%, RR 1.62 [95% CI 1.10-2.37]). Twins of PCOS mothers had more often low birthweight (48% versus 39%, adjusted RR 1.40 [95% CI 1.09-1.80]). This difference disappeared when adjusting for gestational age. No risk difference was found for caesarean section, pre-eclampsia, low 5-minute Apgar score or perinatal mortality. The ris...Continue Reading

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Citations

May 7, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·Nicolas Galazis
Aug 25, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·Y B JeveJ C Konje
Jun 29, 2015·Human Reproduction Update·Stefano PalombaBart C J M Fauser
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Jan 24, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Romina FornesElisabet Stener-Victorin
Jan 24, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mahnaz Bahri KhomamiLisa J Moran
Feb 21, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mahnaz Bahri KhomamiLisa J Moran
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Jul 19, 2016·Current Opinion in Obstetrics & Gynecology·Asma JavedAndrea E Bonny
Sep 28, 2017·Journal of Assisted Reproduction and Genetics·José BellverUNKNOWN Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF)
Feb 5, 2021·PloS One·Heiddis ValgeirsdottirAnna-Karin Wikström
Aug 25, 2020·American Journal of Obstetrics and Gynecology·Snigdha Alur-GuptaAnuja Dokras

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