Pregnancy and the Postpartum Period in Women With Relapsing-Remitting Multiple Sclerosis Treated With Old and New Disease-Modifying Treatments: A Real-World Multicenter Experience

Frontiers in Neurology
Aurora ZanghìF Patti

Abstract

Introduction: Trends of disease activity during pregnancy, the postpartum period, and until 24 months from the delivery in the era of new drugs for the treatment of relapsing-remitting multiple sclerosis (RRMS) need to be investigated. Methods: In this cross-sectional Italian multicenter study, women with RRMS were included; the disease-modifying treatment (DMT) at the time of conception included were: interferons, glatiramer acetate, teriflunomide, dimethyl fumarate, fingolimod, and natalizumab. The main outcome of the study was to determine the rate of relapse occurrence during pregnancy and the postpartum period in all women grouped for each DMT. The secondary outcome was to determine the overall disease activity assessed by NEDA 3 (relapse, disability level, and radiological activity) at 24 months from the date of delivery. Results: Completed data were available for 81 pregnancies (in 74 women). Women on interferons and glatiramer had longer disease duration than women on dimethyl fumarate, fingolimod, and natalizumab (p < 0.05). Overall, we recorded 25 relapses during pregnancy (11 in 11 women) and the postpartum period (14 in 14 women). Natalizumab was the most commonly DMT in women (3) who experienced relapses during pre...Continue Reading

References

Jul 31, 1998·The New England Journal of Medicine·C ConfavreuxT Moreau
Dec 8, 2007·Clinical and Experimental Immunology·L AirasUNKNOWN Finnish Multiple Sclerosis and Pregnancy Study Group
Jun 10, 2009·Archives of Neurology·Annette Langer-GouldLorene M Nelson
May 7, 2010·Neurology·Eva HavrdovaGiancarlo Comi
Mar 16, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·A FinkelsztejnY D Fragoso
Jul 8, 2011·Neurology·E PortaccioUNKNOWN MS Study Group of the Italian Neurological Society
Sep 14, 2012·Therapeutic Advances in Neurological Disorders·Kerstin HellwigRalf Gold
Oct 11, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Stella E HughesUNKNOWN MSBase study group
Apr 9, 2014·BMJ Case Reports·Aldrin Anthony Dung Dung, Akhila Kumar Panda
May 23, 2014·Frontiers in Immunology·Anne SchumacherAna Claudia Zenclussen
Sep 4, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Rebecca S RomeroJöerg-Peter Bugge
Nov 20, 2014·Expert Opinion on Drug Safety·Patricia K Coyle
Jun 23, 2015·Expert Review of Neurotherapeutics·Emanuele D'AmicoFrancesco Patti
Jul 22, 2015·Multiple Sclerosis and Related Disorders·Gavin GiovannoniMonica Marta
Feb 26, 2016·International Journal of Molecular Sciences·Emanuele D'AmicoFrancesco Patti
May 3, 2016·Therapeutic Advances in Neurological Disorders·Patricia K Coyle
Mar 7, 2018·International Journal of MS Care·Magnhild Sandberg-WollheimPatricia K Coyle
Nov 15, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maria TrojanoUNKNOWN Italian Multiple Sclerosis Register Centers Group
Dec 7, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Gabriel BstehThomas Berger
Jun 5, 2019·Continuum : Lifelong Learning in Neurology·Annette M Langer-Gould
Jun 17, 2019·Multiple Sclerosis and Related Disorders·Raed AlroughaniBassem I Yamout
Jul 1, 2019·Journal of Neurology·Leticia Berenguer-RuizAngel Perez Sempere
Aug 12, 2019·Autoimmunity Reviews·Ai-Lan NguyenVilija G Jokubaitis

❮ Previous
Next ❯

Citations

Jun 11, 2020·Expert Opinion on Pharmacotherapy·Johanna B Andersen, Melinda Magyari
Apr 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Emanuele D'AmicoFrancesco Patti
Jul 27, 2021·Current Opinion in Obstetrics & Gynecology·Guoda VarytėDiana Ramašauskaitė

❮ Previous
Next ❯

Software Mentioned

SPSS
iMed ©

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Continuum : Lifelong Learning in Neurology
Annette Langer-Gould
Multiple Sclerosis : Clinical and Laboratory Research
Gabriel BstehThomas Berger
Multiple Sclerosis : Clinical and Laboratory Research
Stella E HughesMSBase Study Group
© 2021 Meta ULC. All rights reserved