Pregnancy-associated breast cancer: clinicopathological characteristics of 20 cases with a focus on identifiable causes of diagnostic delay

Breast Care
Derman BasaranM Sinan Beksac

Abstract

The primary objective of this study was to evaluate the clinicopathological characteristics of patients with pregnancy-associated breast cancer (PABC), with a special focus on diagnostic delays and the identifiable causes of diagnostic delays. Clinicopathological data of patients treated for PABC between 2003 and 2012 at Hacettepe University Hospital was retrospectively reviewed. 20 patients with PABC were included. The pathological examination revealed predominance of invasive ductal carcinoma (80%), grade III tumors (65%) and advanced-stage (III-IV) disease (75%). In 8 patients (40%), there was a diagnostic delay between occurrence of the presenting symptoms and the initiation of breast mass workup. For these 8 patients, the main identifiable causes of diagnostic delay were the attribution of disease-related symptoms to pregnancy or lactation in 5 (63%) and negligence of symptoms in 2 (25%). PABC mostly presents with advanced-stage disease, and there can be a substantial diagnostic delay before these patients receive treatment. Preconceptional, gestational and postpartum examination of women of reproductive age should include a thorough breast examination and should provide adequate information regarding the physiological cha...Continue Reading

Citations

Feb 14, 2017·The Breast Journal·Christina N Cordeiro, Mary L Gemignani
Mar 13, 2020·Breast Cancer Research and Treatment·Ciara C O'SullivanKaren Lisa Smith
Sep 29, 2019·Breast Care·Ibrahim UstunUgur Berberoglu
Jan 12, 2021·Frontiers in Oncology·Soumaya AllouchAla-Eddin Al Moustafa
Nov 24, 2021·Journal of Adolescent and Young Adult Oncology·Nadom SafiElizabeth Sullivan

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