Pregnancy-associated changes in oligomannose oligosaccharides of human and bovine uromodulin (Tamm-Horsfall glycoprotein)

Glycoconjugate Journal
R M SmagulaA P Sherblom

Abstract

The urinary glycoprotein uromodulin (Tamm-Horsfall glycoprotein) exhibits a pregnancy-associated ability to inhibit antigen-specific T cell proliferation, and the activity is associated with a carbohydrate moiety [Muchmore and Decker (1985) Science 229:479-81; Hession et al., (1987) Science 237:1479-84; Muchmore, Shifrin and Decker (1987) J Immunol 138:2547-53]. We report here that the Man6(7)GlcNAc2-R glycopeptides derived from uromodulin inhibit antigen-specific T cell proliferation by 50% at 0.2-2 microM, and further studies, reported elsewhere, confirm that oligomannose glycopeptides from other sources are also inhibitory, with Man9GlcNAc2-R the most inhibitory of those tested [Muchmore et al., J Leukocyte Biol (in press)]. In this work, we have extended the observation of pregnancy-associated inhibitory activity to a second species, and have compared the oligomannose profile of Tamm-Horsfall glycoprotein (nonpregnant) with that of uromodulin (pregnant) derived from both human and bovine sources. Surprisingly, there was a pregnancy-associated decrease in the total content of oligomannose chains due predominantly to a reduction in Man5GlcNAc2-R and Man6GlcNAc2-R. Man7GlcNAc2-R, which did not decrease with pregnancy, comprise...Continue Reading

References

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Citations

May 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Olczak, T Olczak
Jan 13, 1999·Glycobiology·J J Van RooijenJ F Vliegenthart
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F Serafini-CessiDaniela Cavallone
Apr 18, 2016·Molecular Aspects of Medicine·Ian LokeMorten Thaysen-Andersen
Apr 9, 2017·Physiological Genomics·Lesley A GrahamNicholas R Ferreri
Feb 6, 1999·The Journal of Biological Chemistry·M Tandai-HirumaA Kobata
Dec 11, 2020·Journal of the American Society for Mass Spectrometry·Milani Wijeweera PatabandigeHeather Desaire

Related Concepts

UMOD protein, human
Umod protein, mouse
Metazoa
Carbohydrate Sequence
Bos indicus
Cell Division Phases
Molecular Sieve Chromatography
High Pressure Liquid Chromatography Procedure
SDS-PAGE
Mannose

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