Pregnancy-associated changes in responsiveness of the porcine myometrium to bioactive substances

European Journal of Pharmacology
Takio KitazawaTetsuro Taneike

Abstract

To determine the pregnancy-associated changes in the porcine uterine contractility, the spontaneous contraction and the mechanical responses to bioactive substances of uteri in nonpregnant proestrus and pregnant pigs (25-60 days of gestation) were compared in vitro. Longitudinal muscle (LM) and circular muscle (CM) of the uterus exhibited spontaneous contraction, but the frequency in pregnant pigs was lower than that in the nonpregnant pigs. The duration and force of spontaneous contraction in the pregnant pigs were long and large compared with both in the nonpregnant pigs. L-Nitroarginine methylester (L-NAME) and 2a-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl]-2a,3,4,5-tetrahydro-benzo[cd]indol-2(1H)-one (DR4004) did not change the spontaneous contraction in the uteri of nonpregnant pigs but increased its amplitude in the uteri of pregnant pigs. Isoprenaline inhibited the uterine spontaneous contraction of the nonpregnant and pregnant pigs, and the inhibition was stronger in the pregnant than in the nonpregnant pigs. 5-Hydroxytryptamine also caused inhibition of spontaneous contraction in the uteri of nonpregnant pigs (CM>LM). In the pregnant pigs, sensitivity to 5-hydroxytryptamine increased in a muscle layer-dependent manne...Continue Reading

References

Nov 15, 1984·American Journal of Obstetrics and Gynecology·A R FuchsM S Soloff
Apr 1, 1995·Journal of Autonomic Pharmacology·T TaneikeA Ohga
Feb 1, 1997·Human Reproduction·A MoriS Fujii
Jun 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·T KitazawaT Taneike
Jan 12, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B K KimH Karaki
Mar 3, 1999·Journal of Medicinal Chemistry·C KikuchiM Koyama
Mar 5, 1999·Molecular Human Reproduction·J E NormanI T Cameron
Jan 25, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·M TchirikovH J Schröder
Apr 25, 2000·Biology of Reproduction·K S LindemanC W Emala

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Citations

Nov 30, 2006·Journal of Applied Genetics·Agnieszka OponowiczGenowefa Kotwica
Jun 22, 2007·Seminars in Cell & Developmental Biology·A López Bernal
Mar 24, 2016·Acta Veterinaria Scandinavica·Włodzimierz MarkiewiczJerzy Jan Jaroszewski
Nov 30, 2016·Journal of Animal Science·W Markiewicz, J J Jaroszewski

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