Pregnancy-associated glycoprotein (PAG) family localized in chorionic cells within the epitheliochorial/diffuse placenta of the alpaca (Lama pacos)

Acta histochemica
M MajewskaB Szafranska

Abstract

Pregnancy-associated glycoproteins (PAGs) are abundant embryo-originated products expressed in the pre-placental trophoblast and later in the post-implantational chorionic epithelium of some ungulate species. This paper describes the cellular immunolocalization of the chorionic PAG family in the epitheliochorial placenta type of the alpaca (Lama pacos-Lp), in which the PAGs were named 'LpPAGs'. Placental Lp sections (5 μm) of different females near mid-pregnancy (150 days post coitum; dpc), advanced pregnancy (244-263 dpc) and late pregnancy (347 dpc) were used for cross-species (heterologous-ht) double fluorescent immunohistochemistry (htdF-IHC). The htdF-IHC was performed with primary rabbit polyvalent anti-porcine PAG polyclonals. The LpPAG immuno-complexes were visualized with secondary goat anti-rabbit immunoglobulins-conjugated with Alexa 488 fluorophore (green), among all nuclei of placental cells stained with propidium iodide (red). This is the first study reporting the immunolocalization of the LpPAG family identified by htdF-IHC at the feto/maternal interface during different pregnancy stages of the alpaca. The most dominant and strongest immune-positive LpPAG signals were found in the well-developed chorionic cell la...Continue Reading

References

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Citations

Jun 9, 2017·International Journal of Molecular Sciences·Marta MajewskaBozena Szafranska
Feb 11, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Rhianna M WallaceJonathan A Green
Dec 8, 2019·Tropical Animal Health and Production·Camila de Miranda E Silva ChavesCelia Raquel Quirino
Apr 20, 2018·International Journal of Molecular Sciences·Aleksandra LipkaBozena Szafranska
Jan 9, 2019·Acta histochemica·Grzegorz PanasiewiczBozena Szafranska

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