Pregnancy-associated plasma protein-A: an inhibitor of the complement system

Placenta
P Bischof

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) was purified to homogenicity from third-trimester pregnancy plasma using ion exchange chromatography and affinity chromatography on con A-Sepharose and anti-human serum-Sepharose. The elution of PAPP-A, alpha 2-macroglobulin, Cl-inhibitor and alpha 1-antitrypsin was followed by immuno-diffusion. the eluates were tested for stimulation or inhibition of complement-induced haemolysis. PAPP-A markedly inhibits the haemolytic activity of complement.

References

Nov 1, 1979·British Journal of Obstetrics and Gynaecology·R SmithA Klopper
Sep 1, 1974·The Journal of Clinical Investigation·T M LinW N Spellacy
Jan 1, 1961·International Archives of Allergy and Applied Immunology·E A KABAT

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Citations

Jan 1, 1983·Archives of Gynecology·J G WestergaardJ G Grudzinskas
Nov 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·N A Bersinger
Jul 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·N A ZorinN N Semenkov
Apr 1, 1990·Baillière's Clinical Rheumatology·R M Pope
Aug 1, 1986·British Journal of Obstetrics and Gynaecology·N P ArmstrongJ G Grudzinskas
Nov 1, 1983·The Journal of Experimental Zoology·F W Bazer, R M Roberts
Oct 1, 1981·British Journal of Obstetrics and Gynaecology·P BischofP C Sizonenko
Nov 12, 2016·Functional Ecology·Andrew S FliesKay E Holekamp
Jan 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·M T Dearden-Badet

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