Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet

Experimental Gerontology
Cheryl A ConoverRonald J Marler

Abstract

Obesity is on the rise in westernized countries, and visceral obesity in particular is associated with enhanced risk of developing metabolic disease and accelerated aging. Various dietary restriction regimens have been shown to extend healthy lifespan in a variety of species. However, identification of alternative approaches that could be more acceptable to humans is actively being pursued. We have shown previously that mice deficient in pregnancy-associated plasma protein-A (PAPP-A) have an extended healthy lifespan on a regular chow diet. In this study, we determined the lifespan of PAPP-A knock-out (KO) and wild-type (WT) littermates fed a high fat diet (HFD) starting at 12 months of age. PAPP-A KO and WT mice had equivalent weight gain as measured over 25 weeks on HFD. However, PAPP-A KO mice on HFD had a significant increase in lifespan (P=0.018). Body composition and tissue pathology were assessed in a separate cohort of mice after 30 weeks on HFD. Percent body fat was equivalent in the two groups. However, there was a decrease in visceral fat depot weights and an increase in serum adiponectin levels in PAPP-A KO compared to WT mice. Major pathological differences were seen in kidney, heart and testes, with PAPP-A KO mice...Continue Reading

References

May 5, 2001·Cell·C Kenyon
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Ch Sell
Jul 13, 2004·Annals of the New York Academy of Sciences·Donald K IngramGeorge S Roth
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
Oct 18, 2005·Mechanisms of Ageing and Development·Amie J Dirks, Christiaan Leeuwenburgh
Jun 20, 2006·Trends in Cardiovascular Medicine·Noriyuki OuchiKenneth Walsh
Mar 28, 2008·Aging Cell·Radhika MuzumdarNir Barzilai
Mar 31, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cheryl A ConoverRonald J Marler
Jun 17, 2010·Aging Cell·Cheryl A ConoverMegan A Mason
Feb 24, 2012·Cell Cycle·Adam Spong, Andrzej Bartke
Apr 3, 2012·Trends in Endocrinology and Metabolism : TEM·Cheryl A Conover
Apr 30, 2013·Experimental Gerontology·Yan Y LamEric Ravussin
Sep 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Cheryl A ConoverJames L Kirkland
May 2, 2014·The Journal of Endocrinology·Caroline Davidge-PittsCheryl A Conover

❮ Previous
Next ❯

Citations

Dec 31, 2016·Aging Cell·Cheryl A Conover, Claus Oxvig
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Erik NilssonPeter Stenvinkel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.