Pregnancy-associated plasma protein A, free beta-hCG, nuchal translucency, and risk of pregnancy loss

Obstetrics and Gynecology
Laura GoetzlRonald Wapner

Abstract

To estimate the likelihood of clinical early and late pregnancy loss as a function of first-trimester maternal serum analytes and fetal nuchal translucency measurements. Study subjects were recruited for a National Institute of Child Health and Human Development-sponsored multicenter cohort study initially designed to study the detection of Down syndrome during the first trimester of pregnancy. The cohort consisted of women who had a live fetus between 10 and 14 weeks of gestation and had no significant vaginal bleeding. Women with prior fetal trisomy (T21/18) and those with structural or chromosomal abnormalities in the index pregnancy were excluded. First-trimester screening consisted of pregnancy-associated plasma protein A (PAPP-A), free beta-hCG, and nuchal translucency. Pregnancy loss rates in women with various levels of PAPP-A, free beta-hCG, or nuchal translucency (less than 1st, less than 5th, more than 95th, and more than 99th percentile) were compared with losses in women with normal values (5th to 95th percentile). The mean gestational age at screening of 7,932 women meeting study criteria was 12.1 weeks. Loss rates were only 0.36% at less than 20 weeks after normal free beta-hCG, PAPP-A, and nuchal translucency. C...Continue Reading

References

Nov 13, 1987·JAMA : the Journal of the American Medical Association·J L SimpsonR H Knopp
Jan 1, 1983·American Journal of Obstetrics and Gynecology·J G WestergaardJ G Grudzinskas
Apr 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C N ChristodoulouM Fassoula
Apr 2, 1998·The New England Journal of Medicine·J E HaddowA Johnson
Jul 18, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Jennifer A CrossleyJ Michael Connor
Sep 12, 2002·Prenatal Diagnosis·Yuval YaronAvi Orr-Urtreger
Nov 8, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·C S von KaisenbergUNKNOWN German Speaking Down Syndrome Screening Group
Oct 10, 2003·The New England Journal of Medicine·Ronald WapnerUNKNOWN First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group

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Citations

Nov 28, 2012·Histochemistry and Cell Biology·Ambrogio P LonderoLaura Mariuzzi
Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Karen Filkins, Brian J Koos
Jun 1, 2007·Ultrasound Quarterly·Celeste Sheppard, Lawrence D Platt
Mar 14, 2007·Current Opinion in Obstetrics & Gynecology·Fionnuala M Breathnach, Fergal D Malone
Sep 28, 2012·Proceedings. Biological Sciences·Tim A BrucknerMartin Kharrazi
Jul 11, 2009·BMC Medical Research Methodology·Samantha J LainChristine L Roberts
Jan 1, 2014·Journal of Clinical Medicine·David KrantzJonathan Carmichael
Jan 25, 2013·Evolutionary Applications·Ralph CatalanoMartin Kharrazi
May 13, 2015·European Journal of Epidemiology·Tim I M KorevaarRobin P Peeters
Jul 20, 2010·Clinics in Laboratory Medicine·Laura Goetzl
Jul 20, 2010·Clinics in Laboratory Medicine·Stephen T Chasen
Jan 5, 2017·Thyroid : Official Journal of the American Thyroid Association·Tim I M KorevaarRobin P Peeters
Mar 21, 2018·International Journal of Molecular Sciences·Luana PaulesuCarlo Ticconi
Sep 5, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SpencerK H Nicolaides
Jun 26, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M N Bekker
Nov 11, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·R A CatalanoD Steinsaltz
Sep 2, 2008·Obstetrics and Gynecology·Nerea MaizKypros H Nicolaides
Jan 10, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Kate J BrameldRosanne Stock
Nov 27, 2008·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Robert CoccioloneKaren Shand
Mar 14, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·R A CatalanoM Kharrazi
Oct 18, 2016·Prenatal Diagnosis·Marja KaijomaaVedran Stefanovic
Jul 22, 2005·Prenatal Diagnosis
Sep 26, 2017·Molecular Medicine Reports·Li LiuXiaojun Tan
Apr 23, 2010·Obstetrics and Gynecology·Lorraine Dugoff, UNKNOWN Society for Maternal-Fetal Medicine
Jan 27, 2019·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics and the Society forMaternal-
Jul 6, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sophie HourrierFrançoise Muller
Mar 1, 2011·Clinics in Perinatology·Methodius G Tuuli, Anthony O Odibo

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