PMID: 6169364Oct 1, 1981Paper

Pregnancy-associated plasma protein-A (PAPP-A) and hCG in early pregnancy

British Journal of Obstetrics and Gynaecology
P BischofP C Sizonenko

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is a recently described glycoprotein of unknown biological function. The development of a radioimmunoassay enabled us to measure plasma levels of PAPP-A and human chorionic gonadotrophin (hCG) in 12 non-pregnant volunteers and in 159 women in early pregnancy attending the outpatient clinic for legal abortion. PAPP-A but not hCG was measurable in all non-pregnant women. In pregnant patients (with 36 to 86 days of amenorrhea) hCG reached a peak value (163.1-197.6 ng/ml) between the 9th and the 13th week whereas PAPP-A steadily increased throughout this period of pregnancy. Between the 6th and the 13th week after the last menstrual period, levels of PAPP-A increased proportionally more than hCG. This work provides the first evidence of a PAPP-A production in non-pregnant subjects and the very early marked increase of PAPP-A secretion during pregnancy.

References

Feb 1, 1976·The Journal of Clinical Investigation·T M LinD Kiefer
Nov 1, 1979·British Journal of Obstetrics and Gynaecology·R SmithA Klopper
Jul 16, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·P BischofA Klopper
Sep 1, 1974·The Journal of Clinical Investigation·T M LinW N Spellacy

❮ Previous
Next ❯

Citations

Jul 5, 2013·Lab on a Chip·Maïwenn Kersaudy-Kerhoas, Elodie Sollier
Aug 13, 2008·Human Reproduction·Ilkka Y JärveläAydin Tekay
Apr 1, 1990·Baillière's Clinical Rheumatology·R M Pope
Apr 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ana M Fernández-AlonsoFaustino R Pérez-López
Sep 1, 1982·British Journal of Obstetrics and Gynaecology·P BischofP C Sizonenko
Jun 25, 2015·Clinical Medicine Insights. Reproductive Health·Anna YliniemiMarkku Ryynanen
Dec 22, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Y LeungT K Lau
Jan 26, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Y LeungT K Lau
Dec 1, 1984·British Journal of Obstetrics and Gynaecology·N Bersinger, A Klopper
May 1, 1984·British Journal of Obstetrics and Gynaecology·N Bersinger, A Klopper
Aug 9, 2019·Indian Journal of Clinical Biochemistry : IJCB·Indranil GhoshalKrishnananda Prabhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.