Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.

Indian Heart Journal
Priya GururajanK M Cherian

Abstract

Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874-0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive. Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.

References

Oct 6, 2001·The New England Journal of Medicine·A Bayes-GenisR S Schwartz
Sep 17, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Omar F LaterzaGary B Green
Oct 18, 2005·Journal of the American College of Cardiology·Elena ContiFelicita Andreotti
Dec 13, 2006·International Journal of Cardiology·Eric M Thorn, Ijaz A Khan
Mar 23, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qiu-Ping QinKim Pettersson
Aug 24, 2007·Medical Hypotheses·Xuping LiShenghua Zhou
Feb 19, 2008·Clinical Biochemistry·Kasper Karmark IversenPeter Clemmensen
Sep 16, 2008·Atherosclerosis·Luciano Consuegra-SanchezJuan Carlos Kaski

❮ Previous
Next ❯

Citations

Aug 2, 2013·Multidisciplinary Respiratory Medicine·Serdar BerkIbrahim Akkurt
Apr 18, 2015·Indian Journal of Clinical Biochemistry : IJCB·Nazia ParveenSajitha Krishnan
Mar 12, 2019·Expert Review of Proteomics·Eleni PetraAntonia Vlahou
Nov 21, 2018·Biology·Daniel P Jones, Jyoti Patel
Nov 17, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Christos A PapanastasiouEhrin J Armstrong
Jul 6, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Ali CengizTuncer Tuğ

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.