Pregnancy-associated suppressor cells in mice: functional characteristics of CD3+4-8-45R+ T cells with natural suppressor activity

Journal of Reproductive Immunology
J C Brooks-KaiserD W Hoskin

Abstract

Natural suppressor (NS) cells are MHC-unrestricted regulatory cells with non-specific inhibitory activity for immune responses. In adult mice, NS cells are characteristically found in bone marrow and in splenic tissue following total lymphoid irradiation and cyclophosphamide treatments. Recently, we have shown that the spleens of pregnant mice harbour a population of lymphocytes which resemble NS cells in terms of phenotype and inhibitory activity. In this study, we use positive and negative selection techniques to further characterize splenic pregnancy-associated NS (SPANS) cells as predominantly 'double negative' T cells (CD3+4-8-) bearing receptors for the lectins wheat germ agglutinin and soybean agglutinin, as well as expressing CD45R and the heat-stable J11d.2 antigen. Taken together, these findings lead us to conclude that SPANS cells belong to an immature T cell lineage. In keeping with their T cell phenotype, SPANS cells do not express the natural killer (NK) cell-specific markers NK2.1 and asialoGM1 and do not mediate lytic activity against NK-sensitive YAC-1 cells, although natural cytotoxic activity against WEHI-164 cells was found to co-purify with SPANS cells. Suppressive activity of SPANS cells in mixed lymphocyt...Continue Reading

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Related Concepts

Metazoa
T6 Antigens
SD Antigens
Lymphocyte Culture Test, Mixed
Mice, Inbred CBA
Mice, Inbred DBA
Pregnancy, Animal
T-Cell Receptor
Receptors, Mitogen
Spleen

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