Pregnancy-associated venous insufficiency course with placental and systemic oxidative stress.

Journal of Cellular and Molecular Medicine
Miguel A OrtegaNatalio García-Honduvilla

Abstract

The development of lower extremity venous insufficiency (VI) during pregnancy has been associated with placental damage. VI is associated with increased oxidative stress in venous wall. We have investigated potential disturbance/dysregulation of the production of reactive oxygen species (ROS) in placenta and its eventual systemic effects through the measurement of malondialdehyde (MDA) plasma levels in women with VI. A total of 62 women with VI and 52 healthy controls (HCs) were studied. Levels of nicotinamide adenine dinucleotide phosphate-oxidase 1 (NOX1), 2 (NOX2), inducible nitric oxide synthase (iNOS), endothelial (eNOS), poly(ADP-ribose) polymerase PARP (PARP) and ERK were measured in placental tissue with immunohistochemistry and RT-qPCR. Plasma and placental levels of MDA were determined by colorimetry at the two study times of 32 weeks of gestation and post-partum. Protein and gene expression levels of NOX1, NOX2, iNOS, PARP and ERK were significantly increased in placentas of VI. eNOS activity was low in both study groups, and there were no significant differences in gene or protein expression levels. Women with VI showed a significant elevation of plasma MDA levels at 32 weeks of gestation, and these levels remained ...Continue Reading

References

May 1, 1994·The Journal of Dermatologic Surgery and Oncology·A Cornu-ThenardP H Carpentier
Jan 5, 2001·Human Reproduction·P Kristiansson, J X Wang
Jun 8, 2002·World Journal of Surgery·Jari O LaurikkaMatti Hakama
Sep 1, 2004·BioTechniques·Peter M Vallone, John M Butler
Feb 23, 2005·Annals of Epidemiology·Jennifer L Beebe-DimmerDavid Schottenfeld
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Heidar TavilaniHojatollah Saeidi
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
May 1, 2007·American Journal of Obstetrics and Gynecology·Sandra L HallamoreNathan Lawrentschuk
Aug 1, 2007·Gynecologic and Obstetric Investigation·Aydan BiriIlker Durak
Jan 18, 2008·Journal of Vascular Surgery·Mark H MeissnerDavid S Sumner
May 10, 2008·Phlebology·L RobertsonF G R Fowkes
Nov 28, 2008·Journal of Applied Physiology·Jorge D Erusalimsky
Feb 28, 2009·Aging Cell·Leocadio Rodríguez-MañasCarlos F Sánchez-Ferrer
Oct 23, 2009·The British Journal of Surgery·C S Lim, A H Davies
Oct 28, 2010·Free Radical Biology & Medicine·Edina BakondiTilman Grune
Dec 7, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Graham J Burton, Eric Jauniaux
Feb 17, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Damir RojeIvica Tadin
Sep 29, 2011·Aging·Nikolay L MalininTatiana V Byzova
Aug 1, 2012·PloS One·Hassina MassudiGilles J Guillemin
Aug 25, 2012·Nature Reviews. Cancer·Karen Block, Yves Gorin
Nov 6, 2012·Gene·Shen-Hsi YangAlan J Whitmarsh
Jul 16, 2013·Free Radical Biology & Medicine·Mariam El AssarLeocadio Rodríguez-Mañas
Dec 10, 2013·Oxidative Medicine and Cellular Longevity·Daniëlle M P H J BoestenGeja J Hageman
Jun 21, 2014·Cancer·Mauricio BurottoElise C Kohn
Jan 7, 2015·Chemico-biological Interactions·Mahavir SinghAruni Bhatnagar
Feb 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Arianna VigniniAndrea L Tranquilli
Apr 30, 2015·The Journal of Physiology·Sarah JonesPaul Brownbill
Oct 16, 2015·Chemical Research in Toxicology·Orrette R WauchopeLawrence J Marnett
Jan 29, 2016·Clinical and Experimental Hypertension : CHE·Vandita D'SouzaSadhana Joshi
Feb 26, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S J GordijnW Ganzevoort

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Methods Mentioned

BETA
MDA
biopsies

Software Mentioned

‐ BLAST
AutoDimer
Primer
GraphPad Prism

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