Pregnancy decreases oestrogen receptor alpha expression and pyknosis, but not cell proliferation or survival, in the hippocampus

Journal of Neuroendocrinology
Jodi L PawluskiL A M Galea

Abstract

Motherhood differentially affects learning and memory performance and this effect depends on reproductive experience. In turn, evidence suggests that the effects of oestradiol on learning and memory are mediated through binding to oestrogen receptors in the hippocampus and that this is related to hippocampal neurogenesis. The present study investigated the effect of pregnancy and reproductive experience on ERalpha expression throughout the hippocampus, as well as cell proliferation, new cell survival and cell death (as measured by pyknotic cells) in the granule cell layer of the hippocampus. Three groups of female Sprague-Dawley rats were used: virgin, primigravid and multigravid. All rats were injected with 5-bromo-2-deoxyuridine (BrdU; 200 mg/kg) on the afternoon of impregnation and at matched time-points in virgins. Rats were perfused either during early pregnancy (gestation day 1) or late pregnancy (gestation day 21) after BrdU injection. The results obtained show that, during late pregnancy, females, whether first or second pregnancy, have fewer ERalpha-positive cells in the CA3 region of the dorsal hippocampus than virgin females. In addition during early pregnancy, females have significantly fewer pyknotic cells in the g...Continue Reading

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Citations

Apr 7, 2012·Physiology & Behavior·Kelly G Lambert
Jan 27, 2010·Biochimica Et Biophysica Acta·Cindy K Barha, Liisa A M Galea
Jun 16, 2012·The Journal of Comparative Neurology·M BrusF Lévy
Jun 21, 2015·Neuroscience and Biobehavioral Reviews·Craig H KinsleyDanielle S Stolzenberg
Aug 30, 2018·Journal of Neuroscience Research·Joanna Medina, Joanna L Workman
Aug 10, 2011·Journal of Neuroendocrinology·F LévyM Keller
Jul 22, 2014·Journal of Neuroendocrinology·L A M GaleaD A Slattery
Jun 18, 2020·Frontiers in Cell and Developmental Biology·Gavin A ScottJonathan R Epp
May 18, 2019·Neural Plasticity·Lily WanXiao-Xin Yan
Mar 8, 2011·Hormones and Behavior·Jodi L PawluskiHarry W M Steinbusch
Mar 18, 2019·Frontiers in Neuroendocrinology·Jodi L PawluskiJoseph S Lonstein
Aug 7, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alison J Douglas

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