Pregnancy following homologous prepubertal ovarian transplantation in the dog.

Journal of Experimental & Clinical Assisted Reproduction
J K PulliumG A Tuma

Abstract

In several canine models of hereditary human disease the homozygote dogs die prior to puberty, or have substantially reduced fertility. To create a clinically healthy animal that can be bred, but can also transmit the gene of interest, a model of homologous ovarian transplantation in prepubertal dogs was developed. Six dog leukocyte antigen (DLA) identical littermates underwent transplantation of ovarian cortical strips (n = 2) or the entire ovary (n = 4). Immunosuppression was maintained with cyclosporine and MMF in the immediate post-operative period and cyclosporine alone thereafter. All 6 dogs entered puberty and normal semiannual estrus cycles as demonstrated by both physical changes and increasing serum progesterone. Four dogs were bred to a proven stud male, and one became pregnant. Three viable fetuses with observable heart-beats were detected on ultrasound examination. Although the dog eventually aborted the litter, this work represents the first pregnancy achieved following a prepubertal ovarian transplant in the dog.

References

Feb 1, 1983·The Journal of Endocrinology·R J KemppainenP K Chakraborty
Aug 15, 2001·Transplantation·J K PulliumM J Pinter
Mar 26, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·David T BairdEvelyn Telfer
Jun 9, 2005·The New England Journal of Medicine·Sherman J SilberRoger G Gosden
Mar 24, 2006·Theriogenology·G C W England, M Russo
Mar 30, 2007·The New England Journal of Medicine·Sherman J Silber, Roger G Gosden

❮ Previous
Next ❯

Citations

Jun 10, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Fengyin LiShixian Zhou
Aug 30, 2011·Theriogenology·T TerazonoT Otoi

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
dissection
GAT

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.