Pregnancy impairs baroreflex control of heart rate in rats: role of insulin sensitivity.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
V L BrooksRobert K Goldman

Abstract

Recent studies in rabbits suggest that insulin resistance and reduced brain insulin contribute to impaired baroreflex control of heart rate (HR) during pregnancy; however, the mechanisms are unknown. The rat model is ideal to investigate these mechanisms because much is known about rat brain baroreflex neurocircuitry and insulin receptor locations. However, it is unclear in rats whether pregnancy impairs the HR baroreflex or whether insulin resistance is involved. Therefore, this study tested the hypothesis that in rats pregnancy decreases HR baroreflex sensitivity (BRS) and that this decrease is related to concurrent decreases in insulin sensitivity (IS). BRS was quantified before, during, and after pregnancy using complementary methods: 1) spontaneous BRS (sBRS) derived from sequence method analysis of telemetric, continuous arterial pressure recordings; and 2) maximal BRS of complete sigmoidal baroreflex relationships. IS was measured (hyperinsulinemic euglycemic clamp) to determine whether BRS and IS change in parallel. sBRS was reduced at midgestation [pregnancy day 10 (P10)], returned to nonpregnant (NP) levels on P18, and fell again at late gestation (P20) (sBRS in ms/mmHg: NP, 1.66 + or - 0.04; P10, 1.17 + or - 0.11; P1...Continue Reading

References

Sep 1, 1979·The American Journal of Physiology·R A DeFronzoR Andres
Mar 1, 1992·The American Journal of Physiology·K P Conrad, R D Russ
Jun 1, 1992·The American Journal of Physiology·T Hines, W M Barron
Apr 1, 1987·Acta Physiologica Scandinavica·K OlssonU Thornström
May 1, 1974·The Journal of Physiology·P W Humphreys, N Joels
Jan 1, 1984·The American Journal of Physiology·A LeturqueJ Girard
Jan 1, 1980·Diabetologia·A LeturqueJ Girard
Feb 1, 1995·Clinical and Experimental Pharmacology & Physiology·V L BrooksV S Bishop
Jan 1, 1994·Peptides·R D Russ, B R Walker
Feb 1, 1994·The American Journal of Physiology·M Okada, R D Buñag
Dec 1, 1993·The American Journal of Physiology·G RossiM P Diamond
Jan 1, 1995·Biology of the Neonate·C MuñozE Herrera
Mar 1, 1997·The American Journal of Physiology·S Masilamani, C M Heesch
Feb 1, 1997·The American Journal of Physiology·S M SladekK P Conrad
Oct 10, 1997·The American Journal of Physiology·V L BrooksD M Van Winkle
Nov 15, 1997·The American Journal of Physiology·B F SlangenL L Peeters
May 12, 1998·The American Journal of Physiology·J D LaiprasertC M Heesch
Jun 5, 1998·The American Journal of Physiology·K P O'Hagan, S M Casey
Aug 13, 1999·The American Journal of Physiology·K S CurtisC M Heesch
Nov 15, 2000·American Journal of Hypertension·A VossR Faber
Dec 19, 2000·Neuroscience and Biobehavioral Reviews·R J SchulingkampR B Raffa
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W HuangA F Sved
Jun 8, 2001·The Journal of Clinical Investigation·J NovakK P Conrad
Jul 19, 2001·Annals of the New York Academy of Sciences·C M Heesch, C M Foley
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V L BrooksG D Giraud
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J D LaiprasertC M Heesch
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keila T HigaLisete C Michelini
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kathy A ClowVirginia L Brooks
Apr 15, 2004·Endocrine Reviews·O David Sherwood
Jun 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Harald M StaussAlan Kim Johnson
Feb 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daisy L DaubertVirginia L Brooks
Dec 29, 2007·Advances in Experimental Medicine and Biology·Arundhathi JeyabalanKirk P Conrad
Sep 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·J CachoM P Ramos

❮ Previous
Next ❯

Citations

Jul 21, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ding ZhaoVirginia L Brooks
May 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L BrooksCheryl M Heesch
Dec 15, 2010·Hypertension·Afaf S Azar, Virginia L Brooks
Dec 24, 2010·BMC Complementary and Alternative Medicine·Jing AiBao-Feng Yang
Apr 10, 2012·Gender Medicine·Virginia L BrooksRobert K Goldman
Mar 26, 2015·Physiological Reports·Christopher J LashleyKathleen P O'Hagan
Jun 19, 2019·The Journal of Physiology·Zhigang ShiVirginia L Brooks
Feb 9, 2011·The Journal of Physiology·Priscila A CassagliaVirginia L Brooks
May 6, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lei CaoPaul M Pilowsky
Jan 26, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Priyanka GargKishore Kumar Deepak
Mar 20, 2016·Clinical Science·Michèle BissonPatrice Brassard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
V L BrooksCheryl M Heesch
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Daisy L DaubertV L Brooks
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Robert K GoldmanV L Brooks
© 2022 Meta ULC. All rights reserved