PMID: 8938634Oct 1, 1996Paper

Pregnancy in patients with primary sclerosing cholangitis

Liver
I JanczewskaU Broomé

Abstract

A deterioration of liver function may occur during pregnancy in patients with chronic liver disorder. Primary sclerosing cholangitis (PSC) is a chronic progressive liver disorder with a highly variable and fluctuating course. This study aims at investigating the outcome of pregnancy in patients with PSC and, conversely, the effect of pregnancy on the disease. Thirteen pregnancies in 10 patients with PSC (4 with liver cirrhosis, 6 with mild liver disease) were observed. Seven patients had PSC before pregnancy, 2 developed the disease during pregnancy, and one patient developed PSC 2 months after a normal pregnancy with a normal delivery. Clinical symptoms and biochemical analyses were routinely evaluated during the pregnancy. No gastrointestinal haemorrhage was observed during the pregnancy. Two patients had pruritus and 2 abdominal pain before pregnancy, and these symptoms continued during pregnancy. Abdominal pain was noted in 3 patients lacking this symptom before pregnancy. Four patients without pruritus prior to pregnancy developed this symptom during the pregnancy. In two patients, pruritus was so intense as to bring on premature delivery. Liver tests did not indicate any deterioration during pregnancy. No fetal loss occur...Continue Reading

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Citations

Sep 20, 2007·Expert Opinion on Drug Safety·John A Almeida, Stephen M Riordan
Jan 28, 2005·Inflammatory Bowel Diseases·Jayant A Talwalkar, Keith D Lindor
Feb 28, 2009·World Journal of Gastroenterology : WJG·Noel M Lee, Carla W Brady
Jun 6, 2008·World Journal of Gastroenterology : WJG·Marina-G Silveira, Keith-D Lindor
Nov 16, 2011·British Journal of Hospital Medicine·Misha Moore, Catherine Nelson-Piercy
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
Jul 1, 2016·The American Journal of Gastroenterology·Stella GabetaMichael A Heneghan
Sep 14, 2016·ACG Case Reports Journal·Yasir AbdulqaderAbdul Nadir
Mar 10, 2016·Arquivos De Gastroenterologia·Paulo Lisboa BittencourtPatrícia Oliveira
Dec 4, 2019·Clinical Obstetrics and Gynecology·Catherine M Albright, Emily E Fay
Jun 26, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yukifumi SasamoriTakuya Ayabe
Dec 2, 2004·The American Journal of Gastroenterology·Fabiana S Benjaminov, Jenny Heathcote
Sep 19, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Kais ZakhariaJames H Tabibian
Sep 19, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Monika SarkarNorah A Terrault
Mar 15, 2003·Gastroenterology Clinics of North America·Bimaljit S Sandhu, Arun J Sanyal
Apr 9, 2001·Clinics in Liver Disease·E A Fagan

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