Pregnancy in women with systemic lupus erythematosus (SLE)

European Journal of Internal Medicine
Gabriella Moroni, Claudio Ponticelli

Abstract

For many years pregnancy has been contraindicated in patients with SLE, particularly when kidney involvement was present. Today, pregnancy is no longer considered impossible in women with lupus. Yet, lupus pregnancies are still considered high-risk. The prognosis has considerably improved for pregnant women but the fetal risk, although progressively reduced, is still higher in pregnancies of patients with SLE than in pregnancies of healthy women. Miscarriage, premature delivery, and preeclampsia, as well as heart problems in the baby are the major complications that can occur. In this paper we will review the outcome of pregnant women with SLE, the influence of lupus on fetal outcome, the effects of pregnancy on lupus, and the management of pregnant lupus patients based on our personal experience and the revision of the most recent and significant papers on the subject.

References

Oct 1, 1993·Arthritis and Rheumatism·Murray B UrowitzJ McDonald
Feb 1, 1996·British Journal of Rheumatology·G Ruiz-IrastorzaN M Buchanan
May 15, 2001·Annals of the Rheumatic Diseases·Du Le Thi HuongJ-C Piette
Mar 20, 2002·American Journal of Reproductive Immunology : AJRI·P LuppiJ A Deloia
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gabriella MoroniClaudio Ponticelli
Dec 7, 2002·Obstetrics and Gynecology·Raj Rai, Lesley Regan
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Jan 14, 2005·Annals of the Rheumatic Diseases·D Le Thi ThuongJ-C Piette
Feb 5, 2005·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
Mar 12, 2005·American Journal of Reproductive Immunology : AJRI·Francisco CarmonaJuan Balasch
Sep 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L SoubassiN Zerefos
Sep 24, 2005·Lupus·Megan E B ClowseM Petri
Jun 9, 2006·The New England Journal of Medicine·William O CooperWayne A Ray
Nov 1, 2006·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
Sep 12, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lee Hilary GoldsteinMatitiahu Berkovitch
Feb 26, 2008·American Journal of Obstetrics and Gynecology·M M FaasJ G Aarnoudse
May 6, 2008·American Journal of Obstetrics and Gynecology·Megan E B ClowseAndra H James
May 15, 2009·American Journal of Medical Genetics. Part a·Marlene T AnderkaSonja A Rasmussen
Mar 17, 2010·The Journal of Rheumatology·Dafna D GladmanMurray B Urowitz
Apr 1, 2010·Lupus·Vittorio PengoAmelia Ruffatti
May 12, 2010·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoMika Ito
Aug 7, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Andrew SmythVesna D Garovic
Feb 19, 2011·Archives of Gynecology and Obstetrics·Gabriela LannesFrancinne M Ribeiro
Jun 3, 2011·The Journal of Rheumatology·Kate BramhamCatherine Nelson-Piercy
Jun 15, 2011·American Journal of Medical Genetics. Part a·Chahira Kozma, Jayashree Ramasethu
Jul 7, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Michal J SimchenRachel Pauzner
Oct 11, 2011·American Journal of Obstetrics and Gynecology·Christopher J D McKinlayJane E Harding
Nov 25, 2011·Obstetrical & Gynecological Survey·Alan N BaerMichelle Petri
Dec 27, 2011·Autoimmunity Reviews·Graziela CarvalheirasCarlos Vasconcelos
Jan 27, 2012·Clinical Rheumatology·Miguel A SaavedraLuis J Jara
Feb 10, 2012·American Journal of Medical Genetics. Part a·Maria HoeltzenbeinChristof Schaefer
Aug 14, 2012·Expert Review of Clinical Immunology·George Stojan, Alan N Baer

Citations

Dec 9, 2016·Expert Opinion on Drug Safety·Claudio Ponticelli, Gabriella Moroni
May 17, 2018·Expert Review of Clinical Immunology·Gabriella Moroni, Claudio Ponticelli
Mar 7, 2019·Der Internist·J SchreiberK de Groot
Aug 18, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giulia MallucciArsenio Spinillo
Mar 5, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Sukriti BansalNilum Rajora
Mar 29, 2020·BioMed Research International·Alessandra VecchiéNicolas Vuilleumier

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.