Pregnancy-induced adaptations of the central circadian clock and maternal glucocorticoids

The Journal of Endocrinology
Michaela D WharfeB J Waddell

Abstract

Maternal physiological adaptations, such as changes to the hypothalamic-pituitary-adrenal (HPA) axis, are central to pregnancy success. Circadian variation of the HPA axis is dependent on clock gene rhythms in the hypothalamus, but it is not known whether pregnancy-induced changes in maternal glucocorticoid levels are mediated via this central clock. We hypothesized that hypothalamic expression of clock genes changes across mouse pregnancy and this is linked to altered HPA activity. The anterior hypothalamus and maternal plasma were collected from C57Bl/6J mice prior to pregnancy and on days 6, 10, 14 and 18 of gestation (term=d19), across a 24-h period (0800, 1200, 1600, 2000, 0000, 0400 h). Hypothalamic expression of clock genes and Crh was determined by qPCR, plasma ACTH concentration measured by Milliplex assay and plasma corticosterone concentration by LC-MS/MS. Expression of all clock genes varied markedly across gestation, most notably at mid-gestation when levels of each gene were elevated. The pregnancy-induced increase in maternal corticosterone levels (by up to 14-fold on day 14) was not accompanied by a parallel shift in plasma ACTH (28% lower on day 14 compared with non-pregnant levels). Moreover, while circadian r...Continue Reading

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Citations

Apr 14, 2016·The Journal of Endocrinology·Cassandra C YapJeremy T Smith
May 16, 2018·Journal of Biological Rhythms·Rachael C CrewBrendan J Waddell
Sep 16, 2017·The Journal of Experimental Biology·Moshe NagariGuy Bloch
Mar 12, 2019·Journal of Biological Rhythms·Vendula ČečmanováAlena Sumová
Jul 14, 2016·American Journal of Physiology. Endocrinology and Metabolism·Michaela D WharfePeter J Mark
Mar 5, 2020·Journal of Neuroscience Research·Alexandra M YawHanne M Hoffmann
Feb 15, 2020·British Journal of Pharmacology·Joana BickerAna Fortuna
Aug 18, 2020·Reproductive Sciences·Karike OlivierCaitlin S Wyrwoll
May 4, 2017·Stress : the International Journal on the Biology of Stress·Clara V PeraniDavid A Slattery
Dec 1, 2017·Biology of Reproduction·Rachael C CrewPeter J Mark
Dec 21, 2016·Reproduction, Fertility, and Development·Cassandra C YapJeremy T Smith
Sep 19, 2017·Journal of Biological Rhythms·Peter J MarkBrendan J Waddell
Jan 30, 2021·Frontiers in Neuroscience·Mariana Astiz, Henrik Oster
Apr 30, 2021·Development·Cécile DemarezMariana Astiz

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