Pregnancy is not associated with the progression of HIV disease in women attending an HIV outpatient program

American Journal of Epidemiology
R BessingerS Coughlin

Abstract

The objective of this study was to determine whether pregnancy is associated with an acceleration of human immunodeficiency virus (HIV) disease progression in women who have a pregnancy while HIV infected. A retrospective review of all women aged 15-35 years who attended an HIV outpatient program from January 1989 through August 1995, was undertaken. The 192 women who had a term pregnancy after testing positive for HIV were compared with 164 women who were not pregnant during the same period. The main outcome measures were death, the occurrence of a first acquired immunodeficiency syndrome (AIDS)-defining condition, or a condition indicative of symptomatic HIV. Disease progression was assessed using the Kaplan-Meier method and multivariate proportional hazards models. Compared with nonpregnant women, women with a term pregnancy were significantly more likely to be African-American (88% vs. 78%, p < 0.05), younger than 22 years of age (51 % vs. 11%, p < 0.001), and to have entered the clinic with a higher median CD4 count (519 vs. 433 cells/microl, p < 0.001). After adjusting for entry CD4 count and other factors, pregnancy was not associated with progression to any of the study outcomes. Thus, in women attending a publicly fund...Continue Reading

Associated Clinical Trials

Citations

Oct 2, 2007·Journal of Women's Health·Susan AllenAndre Declercq
Mar 29, 2002·AIDS·Birgit H B van BenthemUNKNOWN European Study on the Natural History of HIV Infection in Women and the Swiss HIV Cohort Study
May 10, 2001·Clinical Obstetrics and Gynecology·L Ahdieh
Aug 13, 2013·Infectious Diseases in Obstetrics and Gynecology·Elisabeth SappenfieldAthena P Kourtis
Feb 14, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Dinah AmonginTwaha Mutyaba
Aug 19, 2007·Tropical Medicine & International Health : TM & IH·Van der Paal LieveHeiner Grosskurth
Jan 15, 2004·Obstetrics and Gynecology Clinics of North America·Helen E Cejtin
Nov 2, 2014·Tropical Medicine & International Health : TM & IH·Clara Calvert, Carine Ronsmans
Oct 2, 2003·American Journal of Obstetrics and Gynecology·Howard MinkoffBruce Thompson
Oct 29, 2008·Infectious Disease Clinics of North America·Helen E Cejtin
Jan 18, 2015·Journal of Neuroimmunology·Jasmina DjikićGordana Leposavić
Jan 9, 2004·British Medical Bulletin·James McIntyre
Feb 15, 2001·AIDS Research and Human Retroviruses·R MarlinkUNKNOWN "Giving Voice to a Silent Epidemic" Working Group
Jun 18, 2009·Current Opinion in HIV and AIDS·Charlotte V Hobbs, Shaffiq M Essajee
Oct 28, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Athena P KourtisUNKNOWN Partners in Prevention HSVHIV Transmission Study and Partners PrEP Study Teams

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