Pregnancy late in rodent life has detrimental effects on the heart

American Journal of Physiology. Heart and Circulatory Physiology
Eunhee ChungLeslie A Leinwand

Abstract

During pregnancy, the heart undergoes significant and numerous changes, including hypertrophy, that are usually described as physiological and reversible. Two aspects of the cardiac response to pregnancy are relatively understudied: advanced maternal age and multiple pregnancies (multiparity). Repeated breeder (RB) mice that have undergone five to seven consecutive pregnancies were euthanized 21 days after the weaning of their last pups and compared with age-matched primiparous, one-time pregnant (O1P) mice. The ages of the older mouse groups were similar (12 ± 1 mo). Pregnancy at a later age resulted in reduced fertility (40%); resorption was 29%, maternal mortality was 10%, and mortality of the pups was 17%. Contractile function as indicated by percent fractional shortening was significantly decreased in O1P and RB groups compared with the old nonpregnant control (ONP) group. There was no pathological induction of the fetal program of gene expression, with the exception of β-myosin heavy chain mRNA, which was induced in O1P compared with ONP mice ( P < 0.05) but not in RB mice. MicroRNA-208a was significantly increased in O1P compared with ONP mice ( P < 0.05) but significantly decreased in RB compared with ONP mice ( P < 0.0...Continue Reading

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Citations

Jun 15, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Christy-Lynn M Cooke, Sandra T Davidge
Dec 18, 2019·Biology of Sex Differences·Chen CheRobin Shoemaker

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Methods Mentioned

BETA
PCR
electrophoresis
MDA
transgenic

Software Mentioned

Image Laboratory

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