Pregnancy loss after first-trimester viability in women with sickle cell trait: time for a reappraisal?

American Journal of Obstetrics and Gynecology
Michelle Y TaylorJohn C Morrison

Abstract

The purpose of this study was to evaluate the obstetric outcomes and pathologic findings in women with sickle cell trait. In this retrospective case control study, pregnant women with sickle cell trait were studied over a 4-year period (2001-2005). The women who were delivered at > 16 weeks of gestation were compared with a cohort group of subjects with normal hemoglobin levels, and the placentas were sent for pathologic evaluation. A total of 180 pregnancies were studied with a like number of control patients. Subjects who had sickle cell trait demonstrated shorter average duration of pregnancy (233 +/- 45 days vs 255 +/- 34 days; P < .001) and lower birth weight (2114 +/- 1093 g vs 2672 +/- 942 g; P < .001). The rate of fetal death was significantly higher among study group patients (3.5% vs 9.7%; P = .015) when compared with the control group. Additionally, in study women, acute ascending amniotic infection and meconium histiocytosis were noted much more frequently. Sickling in the intervillous space and decidual vessels that were not associated with artifactual change was also found among patients sickle cell trait. Patients with sickle cell trait appear to be at increased risk for fetal loss compared with women with normal...Continue Reading

References

Sep 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·I C Baill, F R Witter
Sep 24, 1987·The New England Journal of Medicine·J A KarkC J Ruehle
Feb 1, 1985·American Journal of Obstetrics and Gynecology·J G Pastorek, B Seiler
Oct 1, 1985·American Journal of Obstetrics and Gynecology·H W Foster
Aug 1, 1997·American Journal of Obstetrics and Gynecology·K D Larrabee, M Monga
Aug 15, 1998·American Journal of Obstetrics and Gynecology·R GomezS M Berry
May 3, 2000·American Journal of Epidemiology·A Ashley-KochR S Olney
Oct 18, 2000·Archives of Pathology & Laboratory Medicine·L PantanowitzK Balogh
May 12, 2001·American Journal of Obstetrics and Gynecology·P M SunD Jamieson
Mar 15, 2003·American Journal of Perinatology·David M StamilioGeorge A Macones
Jun 3, 2004·Obstetrics and Gynecology·Graham R SerjeantMinerva Thame
Jun 18, 2004·Obstetrics and Gynecology Clinics of North America·Valerie J RappaportKayon Williams

❮ Previous
Next ❯

Citations

Oct 16, 2010·International Journal of Clinical Practice·S M P J JansA L M Lagro-Janssen
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Bharati Amar TaksandeM Patil
Jun 24, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·T L TanE Oteng-Ntim
Jun 4, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·T L TanE Oteng-Ntim
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Alan Thevenet N Tita, Joseph R Biggio
Dec 8, 2015·Hematology·Rakhi P Naik, Carlton Haywood
Apr 3, 2007·Obstetrics and Gynecology·Allison S BryantAaron B Caughey
Nov 6, 2007·Obstetrics and Gynecology·Alan T N TitaDwight J Rouse
Feb 18, 2020·British Journal of Haematology·Samuel WilsonNigel S Key
Jul 1, 2017·Theoretical Medicine and Bioethics·Benjamin Chin-Yee, Ross E G Upshur
May 8, 2008·Cadernos de saúde pública·Alexandra M WatanabeEhrenfried O Wittig
Apr 13, 2021·Archives of Gynecology and Obstetrics·Jan KasparekGabriela Amstad Bencaiova
Aug 10, 2020·La Revue de médecine interne·C MarcombesJ B Arlet
Nov 25, 2021·JAMA Network Open·Silvia P CanelónMary Regina Boland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.