Pregnancy outcome after in utero exposure to valproate : evidence of dose relationship in teratogenic effect

CNS Drugs
Orna Diav-CitrinAsher Ornoy

Abstract

Valproate is a first-line antiepileptic agent and is also used in the treatment of bipolar disorder and migraine. It is a known human teratogen. The objective of the study was to evaluate the teratogenic risk of valproate. All callers who contacted the Israeli Teratology Information Service (TIS) between 1994 and 2004 for information about gestational exposure to valproate were enrolled in the study. After the expected date of delivery, these women were followed up by telephone interview about their pregnancy outcome using a structured questionnaire. Data obtained from women who contacted the TIS about valproate exposure during pregnancy were then compared with data obtained from callers who were counselled for nonteratogenic exposures over the same timeframe. The main outcome measure was the rate of major congenital anomalies. The outcomes of 154 valproate-exposed pregnancies (96.1% at least in the first trimester) were compared with those of 1315 pregnancies of women in the TIS database who were counselled for nonteratogenic exposures. The rate of major anomalies (some multiple) in the valproate group exposed in the first trimester was higher compared with controls after exclusion of genetic or cytogenetic anomalies (8 of 120...Continue Reading

References

Jun 1, 1987·European Journal of Epidemiology·R BertolliniE Robert
Jan 1, 1988·American Journal of Medical Genetics·H H ArdingerEdward J Lammer
Oct 21, 1972·Lancet·B D Speidel, S R Meadow
Jan 1, 1973·Acta Obstetricia Et Gynecologica Scandinavica·T Bjerkedal, S L Bahna
Mar 22, 1980·Lancet·N A BrownS Fabro
Oct 23, 1982·Lancet·E Robert, P Guibaud
Nov 13, 1982·Lancet·T BjerkedalE Robert
Feb 1, 1983·Neurology·M E Blaw, R C Woody
Nov 1, 1984·American Journal of Medical Genetics·J H DiLibertiC J Curry
Aug 1, 1980·The Journal of Pediatrics·B DalensJ Gaulme
Mar 1, 1981·The Journal of Pediatrics·M R Gomez
Jul 7, 2000·Journal of Medical Genetics·S J MooreJ C Dean
Feb 26, 2003·Neurology·E KaajaV Hiilesmaa
Feb 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Shawn FriedGideon Koren
Oct 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·Naghme AdabD Chadwick
Nov 3, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Frank J VajdaMervyn J Eadie
Mar 23, 2005·Neurology·D F WyszynskiAntiepileptic Drug Pregnancy Registry
Sep 15, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J MorrowJ Craig
Aug 9, 2006·Neurology·Kimford MeadorNEAD Study Group

Citations

Oct 11, 2013·Human Reproduction·Marleen M H J van GelderNel Roeleveld
Nov 23, 2010·Current Opinion in Psychiatry·Salvatore Gentile
Jan 13, 2009·Clinical Drug Investigation·Salvatore Gentile
Sep 11, 2009·Indian Journal of Psychiatry·Chittaranjan Andrade
Jun 19, 2014·The New England Journal of Medicine·Krista F HuybrechtsSonia Hernández-Díaz
May 13, 2014·Reproductive Toxicology·Sonia Hernández-Díaz, Michael Levin
Dec 24, 2008·Expert Review of Neurotherapeutics·Leslie Citrome
Mar 10, 2012·Expert Opinion on Drug Safety·Salvatore Gentile
Jan 20, 2016·Current Psychiatry Reports·Sabrina J KhanShari I Lusskin
May 18, 2012·The Journal of Headache and Pain·Paola SarchielliGiorgio Zanchin
Oct 22, 2009·British Journal of Clinical Pharmacology·Hila RosenfeldOrna Diav-Citrin
Apr 25, 2012·Bipolar Disorders·Gin S MalhiMichael Gitlin
Jun 9, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Suzan L CarmichaelEdward J Lammer
Jun 20, 2012·American Journal of Medical Genetics. Part a·Bogdan J WlodarczykRichard H Finnell
Mar 25, 2014·European Journal of Medical Genetics·Erin M Shih, John M Graham
Feb 20, 2010·Seizure : the Journal of the British Epilepsy Association·Maria Mazurkiewicz-BełdzińskaAgnieszka Matheisel
Mar 1, 2012·Seizure : the Journal of the British Epilepsy Association·E MawhinneyJ Morrow
Jul 19, 2012·Lancet Neurology·Torbjörn Tomson, Dina Battino
Nov 29, 2016·Expert Review of Neurotherapeutics·Michael Thomson, Verinder Sharma
Jun 28, 2017·Nature Reviews. Urology·Jason K GurneyDiana Sarfati
Nov 8, 2016·The Cochrane Database of Systematic Reviews·Jennifer WestonAnthony G Marson
Jun 22, 2017·Birth Defects Research·Rachel StadelmaierLewis B Holmes
Apr 7, 2020·Paediatric and Perinatal Epidemiology·Dominique HeinkeNational Birth Defects Prevention Study
Jun 7, 2020·Drug and Therapeutics Bulletin·Anja Johansen-Bibby
May 5, 2018·Paediatric Drugs·Gideon KorenAsher Ornoy
Jun 3, 2018·BMC Pregnancy and Childbirth·Alastair Macfarlane, Trisha Greenhalgh
Dec 29, 2018·Current Neuropharmacology·Michele RomoliCinzia Costa
Jul 16, 2020·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Gengcheng YangQ Paula Lei

Related Concepts

Abnormalities, Drug-Induced
Dose-Response Relationship, Drug
Pregnancy Outcome
Prenatal Exposure Delayed Effects
Depakote
Teratology
Antimanic Effect
Congenital Abnormality
Antiepileptic Agents
Bipolar Disorder

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