Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study.

Multiple Sclerosis : Clinical and Laboratory Research
Emmanuelle PauliatUrsula Winterfeld

Abstract

This prospective multicentre cohort study investigated pregnancy outcomes after fingolimod use for multiple sclerosis during pregnancy. Pregnancy outcomes of 63 fingolimod and 62 interferon-β-exposed pregnancies were compared. Rates of major congenital anomalies (MCA) were 4.8% (2/42) in the fingolimod group versus 2.3% (1/44) in the interferon-β group (odds ratio, 2.2; 95% confidence interval, 0.2-24.6). The adjusted hazard ratio for spontaneous abortion in fingolimod versus interferon-β-exposed pregnancies was 0.6 (95% confidence interval, 0.2-1.8). Further studies are needed to definitely rule out a moderately increased MCA risk after fingolimod exposure during pregnancy.

References

Jan 19, 2012·International Journal of Epidemiology·Per Kragh AndersenHein Putter
May 3, 2016·JAMA Neurology·Stacy Ellen HatcherJennifer S Graves
May 20, 2016·Neurology·Ursula WinterfeldThierry Buclin
Sep 19, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Ingrid MeinlTania Kümpfel
Feb 24, 2018·Multiple Sclerosis and Related Disorders·Samira Navardi, Mohammad Ali Sahraian
Dec 14, 2018·Therapeutic Advances in Neurological Disorders·Yvonne GeissbühlerKerstin Hellwig
Jun 12, 2019·Multiple Sclerosis and Related Disorders·Hamed CheraghmakaniSeyed Mohammad Baghbanian

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Citations

Jul 27, 2021·Current Opinion in Obstetrics & Gynecology·Guoda VarytėDiana Ramašauskaitė
Sep 9, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Assunta BiancoMassimiliano Mirabella

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