Pregnancy outcome of systemic lupus erythematosus in relation to lupus activity before and during pregnancy

Journal of the Chinese Medical Association : JCMA
Ming-Jie YangChang-Ching Yeh

Abstract

To analyze the pregnancy complications and pregnancy outcome relating to the disease activity of systemic lupus erythematosus before conception and during pregnancy. Seventy-two pregnancies were collected in a single tertiary medical center within a 5-year period. Twelve pregnancies were terminated due to various causes in the first half of pregnancy. Analysis of pregnancy complications and pregnancy outcome relating to the lupus activity before conception and during pregnancy was made among the remaining 60 pregnancies with gestational length > 26 weeks. The assessment of lupus activity was based on the routine monitoring, including urine routine, white blood cell count, hemoglobin and platelet count, erythrocyte sediment rate, serum titers of C3, C4, and double-stranded DNA. Monitoring of renal function with daily urinary protein loss and clearance rate of creatinine was needed when worsened nephropathy was suspected. The etiologies of the terminated pregnancies were deteriorated nephropathy (6 cases), involvement of central nervous system (1 case), unwanted pregnancy due to drug exposure (3 cases), and two early intrauterine fetal deaths (both during the 23(rd) week of gestation). Pregnancy complications were related to the ...Continue Reading

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Citations

Jun 7, 2016·Clinics in Dermatology·Joy WanVictoria P Werth
Jan 27, 2015·Journal of the Chinese Medical Association : JCMA·Peng-Hui WangFa-Kung Lee
Mar 5, 2016·Journal of the Chinese Medical Association : JCMA·Wen-Ling LeePeng-Hui Wang
May 5, 2016·European Journal of Internal Medicine·Gabriella Moroni, Claudio Ponticelli
Sep 21, 2019·PloS One·Syahrul Sazliyana ShaharirRahana Abdul Rahman
Jul 29, 2019·Clinical Rheumatology·Elham RajaeiZeinab Deris Zayeri
Aug 5, 2021·Journal of Tropical Pediatrics·Pattima PakhathirathienGunlawadee Maneenil

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