Pregnancy outcomes among HIV-infected women who conceived on antiretroviral therapy

PloS One
Elizabeth M StringerJudith S Currier

Abstract

As antiretroviral therapy (ART) expands in resource-limited settings, understanding the impact of ART on pregnancy outcomes is critical. We analyzed women who became pregnant on ART while enrolled in a clinical trial (HPTN 052, ACTG A5208, and ACTG A5175); the majority of women were from Africa, with a median age of 29 years. Eligible women were on ART at conception and had a documented date of a last menstrual period and a pregnancy outcome. The primary outcome was non-live birth (stillbirth; spontaneous abortion; elective termination; or ectopic pregnancy) versus live birth. Preterm birth (<37 weeks completed gestation) was a secondary outcome. We used Cox proportional hazards regression models with time-varying covariates. 359 women became pregnant, of whom 253 (70%) met inclusion criteria: 127 (50%) were on NNRTI-based ART, 118 (47%) on PI-based ART, and 8 (3%) on 3-NRTIs at conception. There were 160 (63%) live births (76 term and 84 preterm), 11 (4%) stillbirths, 51 (20%) spontaneous abortions, 28 (11%) elective terminations, and 3 (1%) ectopic pregnancies. In multivariable analysis adjusted for region, parent study, and pre-pregnancy ART class, only older age was associated with increased hazard of preterm birth [HR: 2.4...Continue Reading

References

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Citations

May 3, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dorothy SebikariMary Glenn Fowler
Jun 1, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Graziella FavaratoClaire Thorne
Oct 21, 2019·Current HIV/AIDS Reports·Allison Ross EckardNancy L Hagood
Mar 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marian LovedayJames A Seddon
Jun 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gerhard TheronMary Glenn Fowler
Aug 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shahin Lockman, Victor De Gruttola
Jul 12, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dorothy SebikariMary Glenn Fowler
Sep 15, 2020·Clinical Ophthalmology·Alemayehu Mekonnen GezmuBritt Nakstad
Feb 2, 2021·Expert Review of Anti-infective Therapy·Samia Aleem, Zulfiqar A Bhutta
Jan 7, 2021·Prenatal Diagnosis·Kristin Harris, Mark H Yudin
Apr 10, 2021·AIDS Patient Care and STDs·Gundolf SchuettfortAnnette E Haberl
Apr 28, 2021·Mucosal Immunology·Evgeniya V Shmeleva, Francesco Colucci
May 15, 2021·Developmental Medicine and Child Neurology·Gabriela ToledoTessa Goetghebuer
Jun 1, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Verónica Zaga-ClavellinaDaniel Ortuño-Sahagún
Aug 4, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Alfonso MateCarmen M Vázquez
Aug 20, 2021·Journal of Thrombosis and Haemostasis : JTH·Elise SchapkaitzHarry R Büller
Sep 4, 2021·HIV Medicine·Anna HachfeldUNKNOWN Swiss HIV Cohort Study, the Swiss Mother, Child HIV Cohort Study (MoCHiV)

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Methods Mentioned

BETA
contraception
pregnancy tests

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