Pregnancy outcomes among women with beta-thalassemia trait

Archives of Gynecology and Obstetrics
Chitrakan CharoenboonTheera Tongsong


To compare the obstetric outcomes between pregnant women affected by beta-thalassemia trait and normal controls. A retrospective cohort study was conducted on singleton pregnant women complicated by beta-thalassemia trait and normal controls, randomly selected with the controls-to-case ratio of 2:1. All were low-risk pregnancies without underlying medical diseases and fetal anomalies. The pregnancies undergoing invasive prenatal diagnosis were excluded. A total of 597 pregnant women with beta-thalassemia trait and 1194 controls were recruited. Baseline characteristics and maternal outcomes in the two groups were similar, except that hemoglobin levels were slightly lower in the study group. The prevalence of small for gestational age and preterm birth tended to be higher in the study group but not reached the significant levels but the rate of low birth weight was significantly higher in the study group (relative risk 1.25; 95 % CI 1.00-1.57). Additionally, abortion rate was also significantly higher in the study group (relative risk 3.25; 95 % CI 1.35-7.80). Beta-thalassemia trait could minimally, but significantly, increase risk of low birth weight but did not increase rates of maternal adverse outcomes.


Nov 15, 2002·International Journal of Hematology·Suthat Fucharoen, Pranee Winichagoon
May 27, 2005·The Journal of Obstetrics and Gynaecology Research·Supatra SirichotiyakulTheera Tongsong
Sep 26, 2008·Archives of Gynecology and Obstetrics·Kuntharee TraisrisilpTheera Tongsong
Nov 26, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Theera TongsongSuchaya Luewan
Dec 17, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suchaya LuewanTheera Tongsong
May 18, 2013·Archives of Gynecology and Obstetrics·Tharangrut HanprasertpongSavitree Pranpanus


Sep 19, 2018·Journal of Obstetrics and Gynaecology of India·Anahita Chauhan, Madhva Prasad
Apr 12, 2021·Archives of Gynecology and Obstetrics·Jan KasparekGabriela Amstad Bencaiova

Related Concepts

Fetal Growth Retardation
Gestational Age
Low Birth Weight Infant
Neonatal Prematurity
Pregnancy Complications, Hematologic
Pregnancy Outcome
Antenatal Screening Procedures
Retrospective Studies
Nested Case-Control Studies
Thalassemia Minor

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