Pregnancy outcomes among women with hemoglobin E trait

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Walairat KemthongTheera Tongsong

Abstract

To compare the maternal and fetal outcomes between pregnant women complicated with hemoglobin E (HbE) trait and normal controls. A retrospective cohort study was conducted by assessment of the database of maternal-fetal medicine units from January 2003 to December 2013 to identify singleton pregnant women complicated by HbE trait. Pregnancies with medical complications or fetal anomalies were excluded. The normal controls were low-risk pregnancies and were non-carrier status for thalassemia and hemoglobinopathy. During the study period, 1073 women with HbE trait and 2146 normal controls were included. The baseline characteristics of the two groups were comparable except that the number of prenatal visit was statistically higher in study group (8.55 ± 3.03 versus 7.85 ± 4.33, p = <0.001). Most pregnancy outcomes were not significantly different. However, the rate of asymptomatic bacteriuria was minimally higher in the study group, 3.5% versus 2.3%; p = 0.042 (relative risk 1.19; 95%CI: 0.98-1.43). Note that the rates of gestational diabetes tend to be higher in the group of HbE trait (7.6% versus 6.8%), but did not reach a statistical level. The HbE trait does not significantly increase risk of common adverse pregnancy outcomes,...Continue Reading

References

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Citations

Sep 19, 2018·Journal of Obstetrics and Gynaecology of India·Anahita Chauhan, Madhva Prasad

Related Concepts

Congenital Abnormality
Complication
Pharmaceutical Preparations
Hemoglobin E
Hemoglobinopathies
Pregnant Women
Thalassemia
Woman
Gestational Diabetes
Evaluation

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